CAS No.: 1103522-45-7
Aprocitentan Catalog No. CSN17466
Synonyms: ACT-132577;Despropyl Macitentan
ACT-132577 is the major and pharmacologically active metabolite of macitentan), which is dual ETA/ETB endothelin (ET) receptor antagonist designed for tissue targeting.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02050802 Healthy Phase 1 Completed - Germany ... more >> Parexel International GmbH Berlin, Germany, 14050 Collapse << NCT03389321 Healthy Subjects Phase 1 Completed - Germany ... more >> CRS Clinical Research Services Mannheim Mannheim, Germany, 68167 Collapse << NCT03215966 Healthy Subjects Phase 1 Completed - Germany ... more >> CRS Clinical Research Services Mannheim Mannheim, Germany, 68167 Collapse << - 更多
- 参考文献
- [1] Zhang J, Geng P, et al. Pharmacokinetic study of ACT-132577 in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry. Int J Clin Exp Med. 2015 Oct 15;8(10):18420-6.
- [2] Iglarz M, Binkert C, et al. Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist. J Pharmacol Exp Ther. 2008 Dec;327(3):736-45.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1103522-45-7 | 储存条件 |
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| 分子式 | C16H14Br2N6O4S | 运输 | 蓝冰 | |
| 分子量 | 546.19 | 别名 | ACT-132577;Despropyl Macitentan |
