91037-65-9|Arg-Gly-Asp-Ser|CsnPharm

CAS No.: 91037-65-9

Arg-Gly-Asp-Ser Catalog No. CSN10335

Synonyms: RGDS peptide;Fibronectin tetrapeptide;Fibronectin Inhibitor

Arg-Gly-Asp-Ser (RGDS) is a synthetic integrin antagonist, a specific peptide motif through which extracellular matrix (ECM) components interact with integrin and can modify the behavior of cells.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Integrins mediate cell-cell and cell-extracellular matrix (ECM) interactions and recognize several ECM proteins. One of the major sites mediating integrin action is the Arg-GlyAsp (RGD) motif, present in ECM proteins and in other proteins such as disintegrins. Arg-Gly-Asp-Ser (RGDS) is a synthetic integrin antagonist, a specific peptide motif through which extracellular matrix (ECM) components interact with integrin and can modify the behavior of cells. Pretreatment with RGDS at 2.5 or 5 mg/kg, 1h before LPS, inhibited LPS-induced increases in neutrophil and macrophage numbers, total protein levels and TNF-α and MIP-2 levels, and matrix metalloproteinase-9 activity in bronchoalveolar lavage (BAL) fluid at 4 or 24h post-LPS treatment. RGDS also inhibited LPS-induced phosphorylation of focal adhesion kinase and MAP kinases, including ERK, JNK, and p38 MAP kinase, in lung tissue^[3]. Osteoblast-like MC3T3-E1 cells grown on the RGDS(1 and 5 mM) substrate and treated with 0.1 and 0.5 μM staurosporine showed no significant cell killing which was mediated by phosphatidylinositol 3-kinase^[4]. RGDS at 500 μg/mL exhibited a dose-dependent inhibitory effect on human umbilical vein endothelial cells (HUVECs) adhesion to fibronectin and vitronectin (61% ± 4.3% and 84% ± 6.8% inhibition) and significantly reduced FGF-2–induced proliferation (50% ± 4% inhibition) in a concentration-dependent way. It was found that RGDS treatment induced caspase 8 and caspase 9 activation (1.8 ± 0.02 fold and 2.2 ± 0.2 fold versus control, respectively), while it had no effect on caspase 1 and caspase 3/7 activity^[5].
动物研究
剂量
Mice: 5 mg/kg^[3] (i.p.)

给药途径
i.p.
参考文献

动物研究
剂量	Mice: 5 mg/kg^[3] (i.p.)
给药途径	i.p.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3072 mL
- 11.5362 mL
- 23.0725 mL
- 5 mM
- 0.4614 mL
- 2.3072 mL
- 4.6145 mL
- 10 mM
- 0.2307 mL
- 1.1536 mL
- 2.3072 mL

技术信息

CAS号

91037-65-9

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H27N7O8

运输

蓝冰

分子量

433.42

别名

RGDS peptide;Fibronectin tetrapeptide;Fibronectin Inhibitor

溶解度

DMSO	55.0 mg/mL (126.9 mM)

动物实验配方

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