|2-(4-氧代-3-((5-(三氟甲基)苯并[d]噻唑-2-基)甲基)-3,4-二氢噻吩并[3,4-d]哒嗪-1-基)乙酸|CsnPharm

CAS No.: 2170729-29-8

Synonyms: govorestat

AT-007 is a central nervous system (CNS) penetrant Aldose Reductase inhibitor (ARI) in Phase 1/2 development for treatment of Galactosemia.

规格	价格	促销价格	库存	数量

400-920-2911

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400-920-2911

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描述Aldose Reductase (AR) is responsible for formation of a toxic metabolite of galactose, called galactitol, which has been shown to be responsible for many of the long-term complications in Galactosemia^[1]. AT-007 is an orally active central nervous system (CNS) penetrant AR inhibitor for treatment of Galactosemia with an IC₅₀ value of 100 pM. AT-007 reduces toxic galactitol levels and prevents disease complications in an animal model of Galactosemia^[1].

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技术信息

CAS号	2170729-29-8	储存条件	粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C17H10F3N3O3S2	运输	蓝冰
分子量	425.40	别名	govorestat

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