|(2R,4aR,6aR,7S,9R,11aS,11bR)-7-羟基-2-(((2R,3R,4R,5R,6R)-6-(羟甲基)-3-((3-甲基丁酸)氧基)-5-(磺酸基氧基)-4-(磺酸基氧基)四氢-2H-吡喃-2-基)氧基)-11b-甲基-8-亚甲基十四氢-6a,9-甲桥环庚烯并[a]萘-4-羧酸钾|CsnPharm

CAS No.: 102130-43-8

Atractyloside potassium salt/苍术苷钾盐 Catalog No. CSN25584

Synonyms: ATR potassium salt;Atractyloside (potassium salt);Atractyloside Potassium Salt

Atractyloside is a natural compound that acts both an inhibitor of ANT and an apoptosis inducer.

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生物活性

描述The adenine nucleotide translocator (ANT) accomplishes the exchange of ATP from the mitochondrial matrix with cytoplasmic ADP^[1].Atractyloside potassium salt is a toxic diterpenoid glycoside that can be isolated from the fruits of Xanthium sibiricum. Atractyloside potassium salt is a powerful and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart^[2].Upon cell-death induction, ANT1 becomes a substrate for type 2 transglutaminase(TG2)'s cross-linking activity and the lack of TG2 results in a reduction of apoptosis as well as in a marked sensitivity to the ADP/ATP exchange inhibition by atractyloside^[3].Renal and hepatic pyruvate-stimulated gluconeogenesis were significantly (P < 0.05) inhibited at atractyloside concentrations of > or =500 microM. Accumulation of organic anion p-amino-hippuric acid (PAH) was also inhibited in renal cortical slices at atractyloside concentrations of > or =500 microM^[4]. Atractyloside in large amounts gives rise to massive necrosis, but in vitro studies have shown that at lower doses cells progress to apoptosis^[5].In vitro proximal tubular cells are selectively sensitive to atractyloside, whereas other renal cell types are quite resistant. There are also differences in the response of liver and renal tissue to atractyloside^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2453 mL
- 6.2267 mL
- 12.4535 mL
- 5 mM
- 0.2491 mL
- 1.2453 mL
- 2.4907 mL
- 10 mM
- 0.1245 mL
- 0.6227 mL
- 1.2453 mL

技术信息

CAS号

102130-43-8

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C30H44K2O16S2

运输

蓝冰

分子量

802.99

别名

ATR potassium salt;Atractyloside (potassium salt);Atractyloside Potassium Salt;Atractyloside Potassium;苍术苷钾盐;白术苷钾盐

溶解度

DMSO	100.0 mg/mL (124.5 mM)

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