CAS No.: 1314217-69-0
AZD-8529 mesylate Catalog No. CSN26700
Synonyms: AZD-8529
AZD-8529 is a a positive allosteric modulator at the mGluR2 receptor. AZD8529 decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. AZD8529 potentiated agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus, and striatum. In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not affect food self-administration. AZD8529 also reduced nicotine priming- and cue-induced reinstatement of nicotine seeking after extinction of the drug-reinforced responding. In rats, AZD8529 decreased nicotine-induced accumbens dopamine release. The positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
|---|
400-920-2911
sales@csnpharm.cn
tech@csnpharm.cn靶点选择性
生物活性
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1314217-69-0 | 储存条件 |
|
|||
| 分子式 | C25H28F3N5O6S | 运输 | 蓝冰 | |||
| 分子量 | 583.58 | 别名 | AZD-8529 | |||
| 溶解度 |
|
动物实验配方 |
