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CAS No.: 256376-24-6

BAY 41-2272 Catalog No. CSN15709

Synonyms: BAY 41-2272

BAY 41-2272 is an activator of guanylate cyclases (sGC).

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述BAY 41-2272 is a potent sGC stimulator. BAY 41-2272 activates sGC by an NO-independent, but haem-dependent mechanism. BAY 41-2272 stimulated recombinant sGC at concentration ranging in 0.1nM to 100μM, which could not be blocked by high concentrations (65μM) of the NO scavengers PTIO. BAY 41-2272 at concentrations as low as 10–100 nM could stimulate sGC to a level that would be expected to cause biologically important increases in cGMP. Combination with NO could potentiate the BAY 41-2272 on the reaction. BAY 41-2272 exhibited anti-aggregatory as tail-bleeding time was prolonged in rats dosed of 0.3-3mg/kg BAY 41-2272 orally. Oral administration of BAY 41-2272 at dose of 1-10mg/kg to hypertensive rats induced a dose-dependent and long-lasting decrease in mean arterial blood pressure.
作用机制BAY 41-2272 binds to α1-subunit of sGC through Cys 238 and Cys 243.^[1]
动物研究
剂量
Rabbit: 0.1 mg/kg - 1 mg/kg^[2] (i.v.); 1 mg/kg - 10 mg/kg^[2] (p.o.) Mice: 0.3 mg/kg - 10 mg/kg^[3] (i.p.) Rat: 10 mg/kg^[4] (p.o.)

给药途径
i.v., p.o., i.p., p.o.
参考文献

动物研究
剂量	Rabbit: 0.1 mg/kg - 1 mg/kg^[2] (i.v.); 1 mg/kg - 10 mg/kg^[2] (p.o.) Mice: 0.3 mg/kg - 10 mg/kg^[3] (i.p.) Rat: 10 mg/kg^[4] (p.o.)
给药途径	i.v., p.o., i.p., p.o.

[1] Stasch JP, Becker EM, et al. NO-independent regulatory site on soluble guanylate cyclase. Nature. 2001 Mar 8;410(6825):212-5.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7748 mL
- 13.8740 mL
- 27.7479 mL
- 5 mM
- 0.5550 mL
- 2.7748 mL
- 5.5496 mL
- 10 mM
- 0.2775 mL
- 1.3874 mL
- 2.7748 mL

技术信息

CAS号

256376-24-6

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H17FN6

运输

蓝冰

分子量

360.39

别名

BAY 41-2272

溶解度

DMSO	25.0 mg/mL (69.4 mM)
Water	insoluble

动物实验配方

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