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CAS No.: 298708-79-9

Bay 41-4109 racemate Catalog No. CSN20457

Synonyms: BAY41-4109 Racemic;(±)-BAY 41-4109;BAY-41-4109

BAY-41-4109 racemate can inhibit human hepatitis B virus (HBV) with IC50 of 53 nM.

规格	价格	促销价格	库存	数量

400-920-2911

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tech@csnpharm.cn

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技术信息

生物活性

描述Human hepatitis B virus (HBV) causes a communicable disease that spreads worldwide and has brought about considerable economic losses due to human mortality and morbidity^[3]. BAY 41-4109 racemate is the racemate of BAY 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC₅₀ of 53 nM^[4]. BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers^[5]. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC₅₀s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition^[6]. BAY 41-4109 dose-dependently reduces viral DNA in the liver and plasma with efficacy comparable to 3TC. It also reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs^[4].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5268 mL
- 12.6338 mL
- 25.2677 mL
- 5 mM
- 0.5054 mL
- 2.5268 mL
- 5.0535 mL
- 10 mM
- 0.2527 mL
- 1.2634 mL
- 2.5268 mL

技术信息

CAS号

298708-79-9

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H13ClF3N3O2

运输

蓝冰

分子量

395.76

别名

BAY41-4109 Racemic;(±)-BAY 41-4109;BAY-41-4109

溶解度

DMSO	77.0 mg/mL (194.6 mM)
Water	Insoluble
Ethanol	10.0 mg/mL (25.3 mM)

动物实验配方

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