|(S)-N-(1-(1H-苯并[d]咪唑-2-基)-4-(2-氯乙酰亚胺基)丁基)-[1,1'-联苯基]-4-甲酰胺|CsnPharm

CAS No.: 1802637-39-3

Synonyms: BB-CLA

BB-Cl-amidine is a irreversible peptidylarginine deminase (PAD) inhibitor.

规格	价格	促销价格	库存	数量

400-920-2911

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生物活性

描述BB-Cl-amidine is a novel pan-PAD inhibitor with potency to PAD1-4, with half-life of 1.75h in vivo. BB-Cl-amidine exhibited potency against U2OS osteosarcoma cell viability with EC50 value of 8.8μM post 72-hour treatment. Inhibition of PAD by 20μM or 200μM BB-Cl-amidine could prevent PMA-induced neutrophil extracellular trap formation of bone marrow neutrophils prepared from 8-week-old MRL/lpr mice. And this effect could be observed in an in vivo study of MRL/lpr mice daily subcutaneous injected with BB-Cl-amidine at dose of 1mg/kg from 8 to 14 weeks of age. And improved vascular function, and decreasesd IFN signature in bone marrow and kidney, decreased IC deposition in kidneys and reduced proteinuria, improved skin involvement could be found after administration of BB-Cl-amidine.
动物研究
剂量
Mice: 7.5 mg/kg (i.p.), 1 mg/kg - 10 mg/kg^[1] (i.p.); 1 mg/kg^[2] (s.c.)

给药途径
i.p., s.c.

动物研究
剂量	Mice: 7.5 mg/kg (i.p.), 1 mg/kg - 10 mg/kg^[1] (i.p.); 1 mg/kg^[2] (s.c.)
给药途径	i.p., s.c.

实验方案

技术信息

CAS号	1802637-39-3	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C26H26ClN5O	运输	蓝冰
分子量	459.97	别名	BB-CLA

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