|7,7'-二甲氧基-[4,4'-联-1,3-苯并二噁茂]-5,5'-二甲酸二甲酯|CsnPharm

CAS No.: 73536-69-3

Bifendate/联苯双酯 Catalog No. CSN23579

Synonyms: DDB;联苯酯

Bifendate can reduce the activity of alanine aminotransferase and attenuate alanine aminotransferase hepatic steatosis. It is used as an anti-HBV agent.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Bifendate (DDB) is a synthetic intermediate of Schisandrin C with anti-HBV efficacy in research of chronic hepatitis BCui S, Wang M, Fan G. [Anti-HBV efficacy of bifendate in treatment of chronic hepatitis B, a primary study. Zhonghua Yi Xue Za Zhi. 2002;82(8):538-540. |https://pubmed.ncbi.nlm.nih.gov/12133500/]}. Administration of the usual therapeutic dose of bifendate decreased the plasma concentration of cyclosporine in all subjects, which was companied by a marked decrease in the peak plasma concentration{{Zeng Y, He YJ, He FY, Fan L, Zhou HH. Effect of bifendate on the pharmacokinetics of cyclosporine in relation to the CYP3A4*18B genotype in healthy subjects. Acta Pharmacol Sin. 2009 Apr;30(4):478-84. |https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002280/. Daily administration of bifendate (0.03-1,0g/kg, i.g.) for 4 days decreased hepatic level of total cholesterol and triglyceride in hypercholesterolemic mice, and supplementing the high-fat diet mice with bifendate caused more significant decreases in hepatic total cholesterol and triglyceride levels (25-56%, and 22-24% respectively)^[1].
参考文献

[1] Pan SY, Yang R, Dong H, Yu ZL, Ko KM. Bifendate treatment attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Eur J Pharmacol. 2006;552(1-3):170-175.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3903 mL
- 11.9517 mL
- 23.9034 mL
- 5 mM
- 0.4781 mL
- 2.3903 mL
- 4.7807 mL
- 10 mM
- 0.2390 mL
- 1.1952 mL
- 2.3903 mL

技术信息

CAS号

73536-69-3

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H18O10

运输

蓝冰

分子量

418.35

别名

DDB;联苯酯

溶解度

DMSO	83.0 mg/mL (198.4 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Bifendate/联苯双酯 Catalog No. CSN23579

靶点选择性

请登录您的专属账户

确认信息