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CAS No.: 1675201-83-8
Synonyms: PD-1/PD-L1 inhibitor 1;Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor 1;PD1-PDL1 inhibitor 1
PD-1/PD-L1 inhibitor 1 is a small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of 6 nM.
生物活性
靶点 | PD-L1 IC50:6nM | PD-1 IC50:6nM | PD-1/PD-L1 IC50:6nM |
动物研究 | |
剂量 | Mice: 500 μg/mL, 100 μL[1] (i.p.) |
给药途径 | i.p. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT03469713 | Renal Cancer Metastatic | Phase 2 | Recruiting | July 14, 2020 | Italy ... more >> Struttura Complessa di OncologiaIRCCS- Istituto in Tecnologie Avanzate e Modelli Assistenziali in Oncologia Arcispedale Santa Maria Nuova Recruiting Reggio Emilia, Italy, 42123 Contact: Roberta gnoni, biologist +390522295181 gnoni.roberta@ausl.re.it Sub-Investigator: Carmine Pinto, MD Collapse << |
实验方案
技术信息
CAS号 | 1675201-83-8 | 储存条件 |
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分子式 | C29H33NO5 | 运输 | 蓝冰 | |||||||||||
分子量 | 475.58 | 别名 | PD-1/PD-L1 inhibitor 1;Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor 1;PD1-PDL1 inhibitor 1;PD1-PDL1-IN1 | |||||||||||
溶解度 |
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动物实验配方 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT03469713 | Renal Cancer Metastatic | Phase 2 | Recruiting | July 14, 2020 | Italy ... more >> Struttura Complessa di OncologiaIRCCS- Istituto in Tecnologie Avanzate e Modelli Assistenziali in Oncologia Arcispedale Santa Maria Nuova Recruiting Reggio Emilia, Italy, 42123 Contact: Roberta gnoni, biologist +390522295181 gnoni.roberta@ausl.re.it Sub-Investigator: Carmine Pinto, MD Collapse << |
靶点 | Description | IC50 |
---|---|---|
PD-L1 | IC50:6nM | |
PD-1 | IC50:6nM | |
PD-1/PD-L1 | IC50:6nM |
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