CAS No.: 290315-45-6
BMS 299897 Catalog No. CSN19065
BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM).
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Weissmiller AM, Natera-Naranjo O, et al. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015 Feb 24;10(2):e0118379.
- [2] Meunier J, Villard V, et al. The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl] (2,5-difluorophenyl) amino] ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's disease. Eur J Pharmacol. 2013 Jan 5;698(1-3):193-9.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 290315-45-6 | 储存条件 |
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| 分子式 | C24H21ClF3NO4S | 运输 | 蓝冰 | |
| 分子量 | 511.94 | 别名 |
