CAS No.: 714971-09-2
BMS-599626 Catalog No. CSN12809
Synonyms: AC480
AC480 is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, > 100-fold to VEGFR2, c-Kit, Lck, MET etc.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00093730 Unspecified Adult Solid Tumor,... more >> Protocol Specific Collapse << Phase 1 Completed - United States, California ... more >> Jonsson Comprehensive Cancer Center at UCLA Los Angeles, California, United States, 90095-1781 Collapse << NCT00207012 HER2 or EGFR Expressing Advanc... more >>ed Solid Malignancies Collapse << Phase 1 Completed - France ... more >> Local Institution Villejuif Cedex, France Spain Local Institution Barcelona, Spain Collapse << NCT00095537 Cancer Metast... more >>ases Collapse << Phase 1 Completed - United States, Arizona ... more >> Local Institution Scottsdale, Arizona, United States Local Institution Tucson, Arizona, United States United States, California Local Institution Los Angeles, California, United States Collapse << - 更多
- 参考文献
- [1] Torres MA, Raju U, et al. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011 Aug;29(4):554-61.
- [2] Wong TW, Lee FY, et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 714971-09-2 | 储存条件 |
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| 分子式 | C27H27FN8O3 | 运输 | 蓝冰 | |
| 分子量 | 530.55 | 别名 | AC480 |
