生物活性

• 描述BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4, as well as the VEGF receptor kinases.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00479583	Cancer	Phase 1	Completed	-	United States, Alabama ... more >> University Of Alabama At Birmingham Birmingham, Alabama, United States, 35294 United States, Pennsylvania Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111 France Local Institution Saint-Herblain Cedex, France, 44805 Local Institution Villejuif, France, 94805 Collapse <<
  NCT01068704	Breast Cancer	Phase 2	Completed	-	United States, Texas ... more >> Texas Oncology-Abilene Abilene, Texas, United States, 79606 Texas Oncology-Beaumont Beaumont, Texas, United States, 77702 Us Oncology Central Pharmacy Fort Worth, Texas, United States, 76177 United States, Washington Yakima Valley Memorial Hospital/North Star Lodge Yakima, Washington, United States, 98902 Argentina Local Institution Rosario, Santa Fe, Argentina, S2000DSK Local Institution La Rioja, Argentina, 5300 Mexico Local Institution Colima, Mexico, 28030 Peru Local Institution Lima, Peru, 34 Collapse <<
  NCT00329004	Cancer Tumor	Phase 1	Completed	-	United States, Indiana ... more >> Indiana University Med Center Indianapolis, Indiana, United States, 46202 United States, Texas The University Of Texas Md Anderson Cancer Center Houston, Texas, United States, 77030 Canada, Ontario Local Institution Ottawa, Ontario, Canada, K1H 8L6 Local Institution Toronto, Ontario, Canada, M5G 2M9 France Local Institution Toulouse, France, 31052 Local Institution Villejuif, France, 94805 Spain Local Institution Barcelona, Spain, 08035 Collapse <<

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• 参考文献

• [1] Nokihara H, Yamamoto N, et al. A phase I study of BMS-690514 in Japanese patients with advanced or metastatic solid tumors. Cancer Chemother Pharmacol. 2012 Oct;70(4):559-65

  [2] Wong TW, Lee FY, et al. Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families. Clin Cancer Res. 2011 Jun 15;17(12):4031-41.