CAS No.: 1643368-58-4
BMS-986142 Catalog No. CSN20297
BMS-986142 is a potent, selective, reversible BTK inhibitor. BMS-986142 shows BTK IC50 = 0.5nM and human WB IC50 = 90 nM.
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生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02843659 Sjögren's Syndrome Phase 2 Terminated(Inability to meet p... more >>rotocol objectives) Collapse << - - NCT02843659 - - Terminated(Inability to meet p... more >>rotocol objectives) Collapse << - - NCT02832180 Arthritis Phase 1 Completed - United States, Florida ... more >> Miami Research Associates Miami, Florida, United States, 33143 United States, Indiana Covance Evansville Clinical Research Unit Evansville, Indiana, United States, 47710 Collapse << - 更多
- 参考文献
- [1] Lee SK, Xing J, et al. Safety, pharmacokinetics, and pharmacodynamics of BMS-986142, a novel reversible BTK inhibitor, in healthy participants. Eur J Clin Pharmacol. 2017 Jun;73(6):689-698.
- [2] Watterson SH, De Lucca GV, et al. Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers. J Med Chem. 2016 Oct 13;59(19):9173-9200.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1643368-58-4 | 储存条件 |
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| 分子式 | C32H30F2N4O4 | 运输 | 蓝冰 | |
| 分子量 | 572.60 | 别名 |
