|BSJ-03-123游离态|CsnPharm

CAS No.: 2361493-16-3

Synonyms: BSJ

BSJ-03-123 is a PROTAC selectively targeting on CDK6, consist of a warhead palbociclib (a CDK inhibitor) linked to a CRBN ligand pomalidomide.

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400-920-2911

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描述BSJ-03-123 is a PROTAC selectively targeting on CDK6, consist of a warhead palbociclib (a CDK inhibitor) linked to a CRBN ligand pomalidomide. BSJ-03-123 led a cellular degradation of CDK6, but not CDK4, at concentration ranging in 50-1000nM post 3h and resulted a time-dependent depletion of CDK6 at concentration of 200nM within 3h. BSJ-03-123 exploited homolog-selective dependency on CDK6 as it caused a potent anti-proliferative effect on CDK6-dependent AML cell lines, such as H358, by inducing a G1 cell-cycle arrest without a measurable increase in apoptosis. Selective depletion of CDK6 by 200nM BSJ-03-123 decreased phosphorylation level of Rb on site S780 which is catalyzed by CDK4/6^[1].
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CAS号	2361493-16-3	储存条件	粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C47H56N10O11	运输	蓝冰
分子量	937.01	别名	BSJ

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