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CAS No.: 314761-14-3

BTSA1 Catalog No. CSN23343

Synonyms: ANA-38

BTSA1 is a BAX activator that binds to the N-terminal activation site with high affinity and specificity, induces conformational changes to BAX leading to BAX-mediated apoptosis.

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技术信息

生物活性

描述BTSA1, a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. BTSA1-induced BAX activation effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells. BAX expression levels and cytosolic conformation regulate sensitivity to BTSA1. BTSA1 potently suppressed human acute myeloid leukemia xenografts and increased host survival without toxicity^[1]. BTSA1, or Bax overexpression successfully abolished the inhibitory effect of L-cystathionine on Hcy-induced MPTP opening, caspase-9 and caspase-3 activation, and HUVEC apoptosis^[2].
参考文献

[1] Reyna DE, Garner TP, Lopez A, Kopp F, Choudhary GS, Sridharan A, Narayanagari SR, Mitchell K, Dong B, Bartholdy BA, Walensky LD, Verma A, Steidl U, Gavathiotis E. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 2017 Oct 9;32(4):490-505.e10
[2] Wang X, Wang Y, Zhang L, Zhang D, Bai L, Kong W, Huang Y, Tang C, Du J, Jin H. L-Cystathionine Protects against Homocysteine-Induced Mitochondria-Dependent Apoptosis of Vascular Endothelial Cells. Oxid Med Cell Longev. 2019 Nov 25;2019:1253289

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3229 mL
- 11.6143 mL
- 23.2285 mL
- 5 mM
- 0.4646 mL
- 2.3229 mL
- 4.6457 mL
- 10 mM
- 0.2323 mL
- 1.1614 mL
- 2.3229 mL

技术信息

CAS号

314761-14-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H14N6OS2

运输

蓝冰

分子量

430.51

别名

ANA-38

溶解度

DMSO	118.0 mg/mL (274.1 mM)
Water	insoluble

动物实验配方

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