CAS No.: 414910-30-8
Casopitant mesylate Catalog No. CSN26553
Synonyms: GW679769B;GW-679769;Zunrisa (EU)
Casopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK1 receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK1 receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.
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技术信息
| CAS号 | 414910-30-8 | 储存条件 |
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| 分子式 | C31H39F7N4O5S | 运输 | 蓝冰 | |
| 分子量 | 712.72 | 别名 | GW679769B;GW-679769;Zunrisa (EU) |
