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CAS No.: 885499-61-6

CCT128930 Catalog No. CSN15730

Synonyms: CCT 128930

CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase.

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400-920-2911

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技术信息

生物活性

描述CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
PC3M cells	-	Function assay	-	Inhibition of PKB in human PC3M cells assessed as GSK3-beta phosphorylation by ELISA, IC50=0.003 μM	20151677
U87MG cells	-	Function assay	-	Inhibition of PKB in human U87MG cells assessed as GSK3-beta phosphorylation by ELISA, IC50=0.66 nM	20151677

参考文献

[1] Yap TA, Walton MI, et al. AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. Clin Cancer Res. 2012 Jul 15;18(14):3912-23.
[2] Yap TA, Walton MI, et al. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol Cancer Ther. 2011 Feb;10(2):360-71.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9254 mL
- 14.6268 mL
- 29.2536 mL
- 5 mM
- 0.5851 mL
- 2.9254 mL
- 5.8507 mL
- 10 mM
- 0.2925 mL
- 1.4627 mL
- 2.9254 mL

技术信息

CAS号	885499-61-6	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C18H20ClN5	运输	蓝冰
分子量	341.84	别名	CCT 128930

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