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CAS No.: 41136-22-5

Ceftezole sodium/头孢替唑钠 Catalog No. CSN23245

Synonyms: CTZ sodium;Alomen;Celoslin

Ceftezole Sodium, the salt form of ceftezole, is a first generation cephalosporin which binds to proteins located on the inner membrane of the bacterial cell wall.

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技术信息

生物活性

描述Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. In in vitro alpha-glucosidase assays, ceftezole was shown to be a reversible, non-competitive inhibitor of yeast alpha-glucosidase with a Ki value of 5.78 x 10(-7) M when the enzyme mixture was pretreated with ceftezole. Using an in vivo streptozotocin-induced mouse model, we confirmed that blood glucose levels decreased by 30% 20 min after ceftezole treatment (10 mg/kg/day) ^[1]. The activity of ceftezole against clinical isolates of Escherichia coli and Klebsiella spp. appeared to be nearly equal to that of cefazolin and higher than those of cephaloridine and cephalothin. Ceftezole exhibited apparent bactericidal activity at the concentrations above the minimum inhibitory concentration (MIC) against both S. aureus and E. coli. Ceftezole, in a single subcutaneous administration, exhibited somewhat less efficacy in mice against intraperitoneal infections with Streptococcus pyogenes, S. pneumoniae, E. coli, K. pneumoniae or P. mirabilis than either cephaloridine or cefazolin^[2]. Ceftezole attained a higher maximum level in rat lymph by intramuscular administration than the other antibiotics tested. The maximum concentration of ceftezole present in the exudate in the rat inflammatory pouch was higher than that of cefazolin. In rabbits with cerebrospinal meningitis induced by infection of Streptococcus pyogenes, the level of ceftezole in the cerebrospinal fluid was several times higher than that in normal rabbits^[3].
参考文献

[1] Lee DS, Lee JM, Kim SU, Chang KT, Lee SH. Ceftezole, a cephem antibiotic, is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity. Int J Mol Med. 2007;20(3):379‐383
[2] Noto T, Nehashi T, Endo H, Saito M, Matsubara S. Ceftezole, a new cephalosporin C derivative I. In vitro and in vivo antimicrobial activity. J Antibiot (Tokyo). 1976;29(10):1058‐1070
[3] Harada Y, Matsubara S, Kakimoto M, Noto T, Nehashi T. Ceftezole, a new cephalosporin C derivative II. Distribution and excretion in parenteral administration. J Antibiot (Tokyo). 1976;29(10):1071‐1082

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1623 mL
- 10.8117 mL
- 21.6234 mL
- 5 mM
- 0.4325 mL
- 2.1623 mL
- 4.3247 mL
- 10 mM
- 0.2162 mL
- 1.0812 mL
- 2.1623 mL

技术信息

CAS号

41136-22-5

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H11N8NaO4S3

运输

蓝冰

分子量

462.46

别名

CTZ sodium;Alomen;Celoslin;Falomesin;头孢替唑钠;头孢唑钠

溶解度

DMSO	143.0 mg/mL (309.2 mM)
Water	170.0 mg/mL (367.6 mM)

动物实验配方

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Ceftezole sodium/头孢替唑钠 Catalog No. CSN23245

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