|CHIR-124游离态|CsnPharm

CAS No.: 405168-58-3

CHIR-124/CHIR-124游离态 Catalog No. CSN16590

Synonyms: N/A

CHIR-124 is a potent Chk1 inhibitor with IC50 of 0.3 nM with 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.

规格	价格	促销价格	库存	数量

400-920-2911

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技术信息

生物活性

描述CHIR-124 is a potent Chk1 inhibitor with IC50 of 0.3 nM with 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
human MDA-MB-435 cells	-	Cytotoxic assay	-	Cytotoxicity against human MDA-MB-435 cells, EC50=0.08 μM	16603354
human MDA-MB-435 cells	-	Cytotoxic assay	-	Cytotoxicity against human MDA-MB-435 cells in presence of camptothecin	16603354

参考文献

[1] Dai Y, Grant S. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res. 2010 Jan 15;16(2):376-83.
[2] Tse AN, Rendahl KG, et al. CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):591-602.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3815 mL
- 11.9074 mL
- 23.8148 mL
- 5 mM
- 0.4763 mL
- 2.3815 mL
- 4.7630 mL
- 10 mM
- 0.2381 mL
- 1.1907 mL
- 2.3815 mL

技术信息

CAS号	405168-58-3	储存条件	粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C23H22ClN5O	运输	蓝冰
分子量	419.91	别名	N/A

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