210825-31-3|CP 424174|CsnPharm

CAS No.: 210825-31-3

Synonyms: CP 424,174

CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM.

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400-920-2911

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400-920-2911

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描述Interleukin-1(IL-1) is a pro-inflammatory cytokine that plays a role in many acute and chronic human diseases, and elevated levels of IL-1 can be measured in human tissue or body fluids from patient with rheumatoid arthritis (RA), osteoarthritis, chronic obstructive pulmonary disease, asthma, inflammatory bowel and other diseases^[1]. CP 424174 is identified as potent inhibitor of stimulus-coupled IL-1β post-translational processing. It blocks the formation of mature IL-1β without increasing the amount of procytokine. It inhibits ATP-induced proteolytic cleavage of pro-IL-1β, measured by secretion of the 17 kDa mature form of IL-1β, in LPS-primed human blood-derived monocytes when used at concentrations of 0.5 and 2.5 µM. CP 424,174 inhibits ATP-induced IL-1α and IL-1β production in LPS-primed mouse peritoneal macrophages (ED50s = 15 and 14 mg/kg, respectively)^[2].
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CAS号	210825-31-3	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C22H29ClN2O4S	运输	蓝冰
分子量	452.99	别名	CP 424,174

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