CAS No.: 42553-65-1
Crocin/西红花苷 Catalog No. CSN16599
Synonyms: Crocin I;Gardenia Yellow;西红花苷
Crocin, a natural product isolated and purified from the stigma of Crocus sativus L., can relax smooth muscles with a great potential to be a candidate for the treatment of asthma, protect liver and skeletal muscle tissue against exercise-induced oxidative damage by preventing reactive oxygen species (ROS) production, improve toxic effects of DZN via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta, protect rat gastric mucosa against ethanol-induced injury via anti-inflammatory, anti-oxidative, anti-apoptotic and mucin-secretagogue mechanisms that are probably mediated by enhanced PGE2 release, significantly inhibit the growth of HO-8910 cells and arrest them in the G0/G1 phase, and also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3.
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- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01278277 Retinal Degeneration ... more >> Genetic Disease Single-Gene Defects Macular Dystrophy Collapse << Phase 1 Phase 2 Active, not recruiting December 2017 Italy ... more >> Policlinico A. Gemelli Rome, Italy, 00168 Collapse << NCT03022253 Patent Ductus Arteriosus Phase 3 Completed - India ... more >> Post Graduate Institute of Medical Education and Research Chandigarh, India, 160012 Collapse << NCT01625442 Metabolic Syndrome ... more >> Hypercholesterolemia Hypertriglyceridemia Hyperglycemia Collapse << Phase 4 Completed - Iran, Islamic Republic of ... more >> Birjand University of medical sciences Birjand, South khorasan, Iran, Islamic Republic of, 9714815395 Collapse << - 更多
- 参考文献
- [1] Xiong Y, Wang J, et al. Anti-asthma potential of crocin and its effect on MAPK signaling pathway in a murine model of allergic airway disease. Immunopharmacol Immunotoxicol. 2015 Jun;37(3):236-43.
- [2] El-Maraghy SA, Rizk SM, Shahin NN. Gastroprotective effect of crocin in ethanol-induced gastric injury in rats. Chem Biol Interact. 2015 Mar 5;229:26-35.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 42553-65-1 | 储存条件 |
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| 分子式 | C44H64O24 | 运输 | 蓝冰 | |
| 分子量 | 976.96 | 别名 | Crocin I;Gardenia Yellow;西红花苷 |
