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CAS No.: 42553-65-1
Synonyms: Crocin I;Gardenia Yellow;西红花苷
Crocin, a natural product isolated and purified from the stigma of Crocus sativus L., can relax smooth muscles with a great potential to be a candidate for the treatment of asthma, protect liver and skeletal muscle tissue against exercise-induced oxidative damage by preventing reactive oxygen species (ROS) production, improve toxic effects of DZN via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta, protect rat gastric mucosa against ethanol-induced injury via anti-inflammatory, anti-oxidative, anti-apoptotic and mucin-secretagogue mechanisms that are probably mediated by enhanced PGE2 release, significantly inhibit the growth of HO-8910 cells and arrest them in the G0/G1 phase, and also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT01278277 | Retinal Degeneration ... more >> Genetic Disease Single-Gene Defects Macular Dystrophy Collapse << | Phase 1 Phase 2 | Active, not recruiting | December 2017 | Italy ... more >> Policlinico A. Gemelli Rome, Italy, 00168 Collapse << |
NCT03022253 | Patent Ductus Arteriosus | Phase 3 | Completed | - | India ... more >> Post Graduate Institute of Medical Education and Research Chandigarh, India, 160012 Collapse << |
NCT01625442 | Metabolic Syndrome ... more >> Hypercholesterolemia Hypertriglyceridemia Hyperglycemia Collapse << | Phase 4 | Completed | - | Iran, Islamic Republic of ... more >> Birjand University of medical sciences Birjand, South khorasan, Iran, Islamic Republic of, 9714815395 Collapse << |
实验方案
技术信息
CAS号 | 42553-65-1 | 储存条件 |
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分子式 | C44H64O24 | 运输 | 蓝冰 | |
分子量 | 976.96 | 别名 | Crocin I;Gardenia Yellow;西红花苷 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT01278277 | Retinal Degeneration ... more >> Genetic Disease Single-Gene Defects Macular Dystrophy Collapse << | Phase 1 Phase 2 | Active, not recruiting | December 2017 | Italy ... more >> Policlinico A. Gemelli Rome, Italy, 00168 Collapse << |
NCT03022253 | Patent Ductus Arteriosus | Phase 3 | Completed | - | India ... more >> Post Graduate Institute of Medical Education and Research Chandigarh, India, 160012 Collapse << |
NCT01625442 | Metabolic Syndrome ... more >> Hypercholesterolemia Hypertriglyceridemia Hyperglycemia Collapse << | Phase 4 | Completed | - | Iran, Islamic Republic of ... more >> Birjand University of medical sciences Birjand, South khorasan, Iran, Islamic Republic of, 9714815395 Collapse << |
NCT03617315 | Dry Eye Meibo... more >>mian Gland Dysfunction Dry Eye Syndromes Collapse << | Not Applicable | Completed | - | Spain ... more >> José-María Sánchez-González Sevilla, Seville, Spain, 41012 Collapse << |
NCT03375814 | Osteoarthritis, Knee | Phase 3 | Active, not recruiting | July 30, 2018 | Iran, Islamic Republic of ... more >> Jaleh Shariati sarabi Mashhad, Razavi Khorasan, Iran, Islamic Republic of Collapse << |
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