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CAS No.: 916603-07-1

CZC-8004 Catalog No. CSN27382

Synonyms: CZC-00008004;Dianilinopyrimidine-01

CZC-8004 is a pan-kinase inhibitor and binds a range of tyrosine kinases, including ABL kinase.

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技术信息

生物活性

描述Aberrant tyrosine kinase activity plays a critical role in many hematologic disorders, including chronic myeloid leukemia characterized by the constitutive activity of BCR-ABL. ABL therefore represents a crucial target for new therapeutic strategies^[3]. CZC-8004 is a pan-kinase inhibitor, with low micromolar IC₅₀ values for tyrosine kinase including ABL kinase. A 50% bead loading gave the highest level of PK (protein kinase) identification for CZC-8004, extracting 55 PKs from a single cell lysate. The CZC-8004 beads extracted 61 and 64 PKs with 55 PKs common across the two bead batches examined^[4].
参考文献

[1] CZC-8004 is a pan-kinase inhibitor, with low micromolar IC50 values for tyrosine kinase.
[2] Bantscheff M, et al. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat Biotechnol. 2007 Sep;25(9):1035-44.
[3] Cilloni D, Saglio G. Molecular pathways: BCR-ABL. Clin Cancer Res. 2012 Feb 15;18(4):930-7.
[4] Deane FM, Lin AJS, Hains PG, Pilgrim SL, Robinson PJ, McCluskey A. FD5180, a Novel Protein Kinase Affinity Probe, and the Effect of Bead Loading on Protein Kinase Identification. ACS Omega. 2017 Jul 31;2(7):3828-3838.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2327 mL
- 16.1634 mL
- 32.3268 mL
- 5 mM
- 0.6465 mL
- 3.2327 mL
- 6.4654 mL
- 10 mM
- 0.3233 mL
- 1.6163 mL
- 3.2327 mL

技术信息

CAS号

916603-07-1

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H16FN5

运输

蓝冰

分子量

309.34

别名

CZC-00008004;Dianilinopyrimidine-01

溶解度

DMSO	62.0 mg/mL (200.4 mM)
Water	Insoluble
Ethanol	6.0 mg/mL (19.4 mM)

动物实验配方

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