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CAS No.: 177355-84-9

DBeQ/P97抑制剂 Catalog No. CSN17154

Synonyms: JRF 12;N,N'-Dibenzylquinazoline-2,4-diamine;DBEQ

DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.

规格	价格	促销价格	库存	数量

400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 p97

IC50:1.5μM
描述P97 ATPase, which is also known as VCP (valosin-containing protein) or TERA (translational endoplasmic reticulum ATPase), has various substrates,such as LC3,HIF1A, CYP3a. It is involved in autophagy, ERAD pathway etc.. DBeQ can inhibit p97 selectively and potently in a reversible and ATP-competitive manner. Different from the conventional proteasome inhibitors, DBeQ affects both the UPS and autophagic protein degradation pathways. DBeQ can also rapidly activate caspases 3/7 and induce cell death, which target p97 in cancer therapy^[1].
作用机制DBeQ binds to the active site of the D2 domain and inhibits p97 in an ATP-competition manner.^[1]

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9375 mL
- 14.6877 mL
- 29.3754 mL
- 5 mM
- 0.5875 mL
- 2.9375 mL
- 5.8751 mL
- 10 mM
- 0.2938 mL
- 1.4688 mL
- 2.9375 mL

技术信息

CAS号

177355-84-9

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H20N4

运输

蓝冰

分子量

340.42

别名

JRF 12;N,N'-Dibenzylquinazoline-2,4-diamine;DBEQ

溶解度

DMSO	67.0 mg/mL (196.8 mM)
Water	Insoluble
Ethanol	5.0 mg/mL (14.7 mM)

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