400-920-2911 sales@csnpharm.cn
您的位置 : 首页 / Epigenetics / HIF / Deferoxamine Mesylate/甲磺酸去铁胺
CAS No.: 138-14-7
Synonyms: Desferrioxamine B mesylate;DFOM;Deferoxamine (mesylate)
Deferoxamine mesylate as a chelating agent used to remove excess iron from the body, treat acute iron poisoning, especially in small children, used to treat hemochromatosis, that can be either genetic or acquired. It has been previously reported to induce hypoxia and hypoxia-inducible factor-1α (HIF-1α) expression.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT00004982 | Iron Overload ... more >> Thalassemia Collapse << | Phase 1 | Completed | - | United States, New York ... more >> Cornell University Medical College New York, New York, United States, 10021 Collapse << |
NCT00447694 | Beta-thalassemia ... more >> Iron Overload Collapse << | Phase 2 | Completed | - | United States, California ... more >> Childrens Hospital of Los Angeles Los Angeles, California, United States, 90027 Children's Hospital and Research Center at Oakland Oakland, California, United States, 94609 United States, Illinois Children's Memorial Hospital Chicago, Illinois, United States, 60614 Collapse << |
NCT00110266 | Myelodysplastic Syndrome ... more >> Iron Overload Collapse << | Phase 2 | Completed | - | - |
实验方案
技术信息
CAS号 | 138-14-7 | 储存条件 |
|
|||||
分子式 | C26H52N6O11S | 运输 | 蓝冰 | |||||
分子量 | 656.79 | 别名 | Desferrioxamine B mesylate;DFOM;Deferoxamine (mesylate);DFO;DFX;Deferoxamine;Deferoxaminum;Deferoxamin;Desferin;Deferrioxamine B;DFOA;Desferal;甲磺酸去铁胺 | |||||
溶解度 |
|
动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT00004982 | Iron Overload ... more >> Thalassemia Collapse << | Phase 1 | Completed | - | United States, New York ... more >> Cornell University Medical College New York, New York, United States, 10021 Collapse << |
NCT00447694 | Beta-thalassemia ... more >> Iron Overload Collapse << | Phase 2 | Completed | - | United States, California ... more >> Childrens Hospital of Los Angeles Los Angeles, California, United States, 90027 Children's Hospital and Research Center at Oakland Oakland, California, United States, 94609 United States, Illinois Children's Memorial Hospital Chicago, Illinois, United States, 60614 Collapse << |
NCT00110266 | Myelodysplastic Syndrome ... more >> Iron Overload Collapse << | Phase 2 | Completed | - | - |
NCT00001203 | - | - | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT02065492 | Thalassemia | Phase 2 Phase 3 | Completed | - | Pakistan ... more >> Aga Khan University Hospital Karachi, Sindh, Pakistan, 74800 Collapse << |
NCT00293098 | - | - | - | - | United States, Pennsylvania ... more >> The Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Collapse << |
NCT00000595 | Anemia (Iron-Loading) ... more >> Beta-Thalassemia Hematologic Diseases Hemoglobinopathies Thalassemia Iron Overload Hemochromatosis Collapse << | Phase 2 | Completed | - | - |
NCT01905774 | - | - | Completed | - | Israel ... more >> Ha'Emek Medical Center Afula, Israel, 18101 Collapse << |
NCT00749515 | Transfusion-dependent Hemachro... more >>matosis Thalassemia Major Sickle Cell Disease Collapse << | Phase 4 | Completed | - | United States, Massachusetts ... more >> Children's Hospital Boston Boston, Massachusetts, United States, 02115 Collapse << |
NCT01996683 | Beta-thalassemia ... more >> Serum Ferritin Iron Chelation Therapy Collapse << | Not Applicable | Unknown | November 2015 | Egypt ... more >> Pediatric Hematology clinic, Ain Shams University Not yet recruiting Cairo, Egypt Principal Investigator: Mohsen S Elalfy, professor Sub-Investigator: Amira A Adly, Assist. prof. Sub-Investigator: Yasmine I Elhenawy, lecturer Collapse << |
NCT01956799 | - | - | Active, not recruiting | December 2018 | Italy ... more >> Ematologia, AO SS. Antonio e Biagio Alessandria, AL, Italy, 15121 Clinica di Ematologia, AOU Ospedale di Torrette Ancona, AN, Italy, 60020 Ematologia con trapianto, AOU Policlinico di Bari Bari, BA, Italy, 70124 Istituto di Ematologia e Oncologia Medica, Policlinico S.Orsola Bologna, BO, Italy, 40138 Ematologia, Spedali Civili Brescia, BS, Italy, 25123 Struttura complessa di Ematologia, ASO S.Croce e Carle Cuneo, CN, Italy, 12100 Cattedra di Ematologia Policlino Careggi Firenze, FI, Italy, 50134 Clinica Ematologica, Università di Genova Genova, GE, Italy, 16132 U.O. Clinica Medicina Interna, IRCCS San Martino IST Genova, GE, Italy, 16132 UO Ematologia e CTMO, Ospedale Civile G. da Saliceto Piacenza, PC, Italy, 29121 Ematologia, Università di Padova Padova, PD, Italy, 35128 Struttura Cattedra di Ematologia e CTMO, AOU di Parma Parma, PR, Italy, 43100 Ematologia e Centro Trapianti, Centro di Riferimento Oncologico della Basilicata Rionero in Vulture, PZ, Italy, 85028 Medicina Interna II Divisione di Ematologia, Ospedale S. Luigi Gonzaga Orbassano, TO, Italy, 10043 Ematologia 2, AOU Città della Salute e della Scienza Torino, TO, Italy, 10126 S.C.D.U. Ematologia e Terapie cellulari, Ospedale Mauriziano Torino, TO, Italy, 10128 UOC Ematologia, Ospedale S.Eugenio Roma, Italy, 00144 Policlinico A.Gemelli Roma, Italy, 00168 UOC Ematologia, AO S. Giovanni Addolorata Roma, Italy, 00184 Ematologia, AO S. Andrea Roma, Italy, 00189 Collapse << |
NCT02875262 | Intracranial Aneurysm ... more >> Subarachnoid Hemorrhage Collapse << | Phase 1 Phase 2 | Not yet recruiting | June 1, 2018 | Netherlands ... more >> Radboudumc Not yet recruiting Nijmegen, Gelderland, Netherlands, 6500 HB Contact: Jeroen Boogaarts, M.D., Ph.D. 0031243615085 jeroen.boogaarts@radboudumc.nl Contact: Joost de Vries, M.D., Ph.D. 0031243615085 joost.devries@radboudumc.nl University Medical Center Groningen Not yet recruiting Groningen, Netherlands, 9713 GZ Contact: Marc van Dijk, M.D., Ph.,D. 00310503616161 j.m.c.van.dijk@umcg.nl Contact: Rob Groen, M.D., Ph.,D. 00310503616161 r.j.m.groen@umcg.nl Collapse << |
NCT00105495 | Thalassemia Major ... more >> Hemosiderosis Collapse << | Phase 4 | Completed | - | Greece ... more >> 1st Department of Pediatrics, Athens University, Aghia Sophia Children's Hospital Athens, Greece, 11527 Aghia Sophia Children's Hospital Athens, Greece, 11527 Italy Ospedale Regionale Microcitemie, Dipartimento di Scienze Cagliari, Sardegna, Italy, 09100 Dipartimento di Scienze e Dell' Adolescenza, University of Turin Turin, Italy, 10126 Collapse << |
NCT03137966 | Diabetic Foot Ulcer | Phase 2 | Not yet recruiting | December 31, 2022 | - |
NCT00658411 | Acute Myeloid Leukemia ... more >> Acute Lymphoblastic Leukemia Myelodysplastic Syndrome Collapse << | Not Applicable | Terminated(Closed due to slow ... more >>patient accrual) Collapse << | - | United States, Massachusetts ... more >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Collapse << |
NCT00658411 | - | - | Terminated(Closed due to slow ... more >>patient accrual) Collapse << | - | - |
NCT00738413 | Thalassemia | Phase 1 Phase 2 | Unknown | December 2009 | United States, New York ... more >> Weill Cornell Medical Center Recruiting New York, New York, United States, 10021 Contact: Robert W Grady, Ph.D. 212-746-3422 rwgrady@med.cornell.edu Contact: Kristen Muirhead, BS 212-746-3264 krm2066@med.cornell.edu Principal Investigator: Robert W Grady, Ph.D. Sub-Investigator: Patricia J Giardina, M.D. Collapse << |
NCT01511848 | Beta-thalassemia Major ... more >> Sickle Cell Disease Iron Hemosiderosis Collapse << | Phase 2 Phase 3 | Unknown | February 2013 | Egypt ... more >> Pediatric Hematology clinic, Ain Shams University Not yet recruiting Cairo, Egypt Collapse << |
NCT01752153 | Immune Abnormalities | Phase 1 | Completed | - | Iran, Islamic Republic of ... more >> Department of Immunology, School of Medicine, Shiraz University of Medical Sciences Shiraz, Fars, Iran, Islamic Republic of Collapse << |
NCT00999349 | Beta-thalassemia Major ... more >> Iron Overload Collapse << | Phase 2 Phase 3 | Unknown | - | Iran, Islamic Republic of ... more >> Isfahan University of Medical Sciences Isfahan, Iran, Islamic Republic of, 81744-176 Collapse << |
NCT02216513 | Subarachnoid Hemorrhage | Early Phase 1 | Terminated(Principle Investiga... more >>tor is moving to another institution and plans to restart this proctocol in the new location.) Collapse << | - | United States, Massachusetts ... more >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Collapse << |
NCT02367248 | Intracerebral Hemorrhage | Phase 1 Phase 2 | Unknown | December 2016 | China ... more >> Department of Neurology,Beijing Shijitan Hospital,Capital Medical University Recruiting Beijing, China, 100038 Contact: Maolin He, MD 0086-010-63926550 maolinh@sina.com Collapse << |
NCT01365104 | Stroke Proble... more >>m of Aging Collapse << | Early Phase 1 | Completed | - | United States, Massachusetts ... more >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Collapse << |
NCT01662895 | Intracerebral Hemorrhage | Phase 2 | Suspended(By DSMB due to incre... more >>ased incidence of ARDS. See modified protocol [NCT02175225) Collapse << | December 2018 | - |
NCT00598572 | Intracerebral Hemorrhage | Phase 1 | Completed | - | United States, Massachusetts ... more >> Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Collapse << |
NCT00901199 | Thalassemia I... more >>ron Overload Collapse << | Phase 4 | Completed | - | United States, California ... more >> CHRCO Oakland, California, United States, 94609 Collapse << |
NCT00349453 | Hemochromatosis | Phase 2 | Completed | - | Switzerland ... more >> Cantonal Hospital, Children's Clinic Aarau, Aargau, Switzerland, 5001 Cantonal Hospital Aarau, Aargau, Switzerland, 5001 Cantonal Hospital Graubünden Chur, Graubünden, Switzerland, 7000 Private practice Arzo, Ticino, Switzerland, 6864 Private practice Lugano, Ticino, Switzerland, 6900 Regional Hospital Lugano, Ticino, Switzerland, 6900 Private practice Riva San Vitale, Ticino, Switzerland, 6826 Private children's practice Brig, Wallis, Switzerland, 3900 Private practice Oerlikon, Zurich, Switzerland, 8050 Private children's practice Bern, Switzerland, 3014 Children's Hospital of Eastern Switzerland St. Gallen, Switzerland, 9006 University Children's Hospital Zurich, Switzerland, 8032 University Hospital Zurich, Switzerland, 8091 Collapse << |
NCT00350662 | Hemochromatosis | Phase 3 | Completed | - | Egypt ... more >> Pediatric Hospital, Cairo University Cairo, Egypt Turkey EGE University Medical School Bornova, Izmir, Izmir, Turkey, 35100 Collapse << |
NCT01369719 | Thalassemia I... more >>ron Overload Transfusion Related Complications Collapse << | Not Applicable | Completed | - | Iran, Islamic Republic of ... more >> Hormozgan University of Medical Sciences (HUMS) Bandar abbas, Hormozgan, Iran, Islamic Republic of, 79145-3388 Collapse << |
NCT02175225 | Intracerebral Hemorrhage | Phase 2 | Active, not recruiting | December 31, 2018 | - |
NCT03085771 | Diabetes Mellitus, Type 1 | Phase 2 | Recruiting | December 12, 2022 | Sweden ... more >> Karolinska University Hospital Recruiting Stockholm, Sweden, 17176 Contact: Sergiu Catrina, ass prof MD +46-8-51770000 sergiu-bogdan.Catrina@ki.se Contact: Neda Ekberg, PhD, MD +46-(0)8 51775449 Neda.Ekberg@ki.se Collapse << |
联系我们
官方电话:400-920-2911
二维码
微信公众号 CSN官网