|(E)-2-([1,1'-联苯]-4-基氨基)-N-羟基-2-氧代乙酰亚胺基氰化物|CsnPharm

CAS No.: 1263303-95-2

Synonyms: Dihydroorotate Dehydrogenase Inhibitor 11;YNN-03952

DHODH-IN-11, a leflunomide derivative, is a weak inhibitor of dihydroorotate dehydrogenase (DHODH) with pKa of 5.03.

规格	价格	促销价格	库存	数量

400-920-2911

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400-920-2911

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描述Dihydroorotate dehydrogenase (DHODH) is the rate-limiting enzyme in the uridine monophosphate (UMP) biosynthetic pathway and mostly located in the inner membrane of mitochondria, catalyzing the transformation of dihydroorotate to orotate dependent of Mg²⁺ and ATP^[1]. DHODH-IN-11 (Compound 14B), a derivative of Leflunomide, is a weak inhibitor of DHODH with a pKa of 5.03. The weak potency of DHODH-IN-11 may be due to the adverse stereochemistry of the oxime structure^[2].
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CAS号	1263303-95-2	储存条件	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C15H11N3O2	运输	蓝冰
分子量	265.27	别名	Dihydroorotate Dehydrogenase Inhibitor 11;YNN-03952

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