|5,5-二甲基噁唑烷-2,4-二酮|CsnPharm

CAS No.: 695-53-4

Synonyms: Dimethyloxazolidinedione;Dimethadion

5,5-Dimethyl-2,4-oxazolidinedione is a cathepsin K inhibitor, it's an anticonvulsant.

规格	价格	促销价格	库存	数量

400-920-2911

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400-920-2911

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生物活性

描述5,5'-Dimethyloxazolidine-2,4-dione (DMO), a weak non-metabolizable acid, is commonly utilized for determining intracellular pH. In these studies, DMO was tested as an inducer of differentiation on the basis that its uptake and subsequent dissociation might transiently raise intracellular pH and activate ion-fluxes critical for triggering maturation. After 5 days of exposure to 40 mM DMO, greater than 60% of HL-60 cells displayed phenotypic and functional changes characteristic of mature granulocytes. DMO was either weak or inactive as an inducer of murine erythroleukemia cell (FLC) differentiation^[2]. Determination of the overall internal pH of the cells, using (14)C-benzoic acid (BA) or DMO, showed that the cells maintain a neutral pH (6.6 to 7.2) over an external pH range of 3.0-7.0^[3]. The internal pH of S. petersenii determined using (14)C-benzoic acid and [2-(14)C]-5,5-dimethyloxazolidine-2,4-dione was pH 7.0-7.5, over an external pH range of 5.0-7.5^[4]. The glucose effect on DMO uptake was concentration-dependent, with half-maximal effect at about 4 mM-glucose and maximum effect at about 10 mM-glucose^[5].
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技术信息

CAS号	695-53-4	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C5H7NO3	运输	蓝冰
分子量	129.11	别名	Dimethyloxazolidinedione;Dimethadion

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