|二苯基氯化碘盐|CsnPharm

CAS No.: 4673-26-1

氯化二亚苯基碘鎓 Catalog No. CSN20629

Synonyms: DPI;Diphenyleneiodonium (chloride);Diphenyleneiodonium Chloride

Diphenyleneiodonium chloride is an agonist of GPR3 with EC50 of 1 μM. It can activate adenylate cyclase.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Transient receptor potential ankyrin 1 (TRPA1) is a Ca²⁺-permeable nonselective cation channel expressed in neuronal and nonneuronal cells and plays an important role in acute and inflammatory pain. Diphenyleneiodonium chloride (DPI), a NADPH oxidase (NOX) inhibitor, also functions as a TRPA1 activator with an EC₅₀ of 1 to 3 μM. Application of DPI at 0.03-10 μM induced a Ca²⁺ response in HEK-TRPA1 cells in a concentration-dependent manner. In inflammatory human synoviocytes where TRPA1 is functionally expressed, 3 μM DPI evoked a Ca²⁺ response when cells were treated with IL1α suggesting that DPI activates endogenous TRPA1 expressed in human synoviocytes^[3]. In human RPE cell line ARPE-19 cells, DPI (0.1, 1, and 10 μM) resulted in a significant decrease of cell proliferation, without vacuolation and detachment of the cells from the dish. Significantly increased level of p53 was detected at 4 h after treatment of DPI^[4]. In mice, intraplantar injection of 2 mM DPI caused a pain-related response which was inhibited by preadministration with HC (a selective TRPA1 antagonist, HC-030031)^[3].
参考文献

[1] Pandey M, Singh AK, et al. Diphenyleneiodonium chloride (DPIC) displays broad-spectrum bactericidal activity. Sci Rep. 2017 Sep 14;7(1):11521.
[2] Osaki T, Uchida Y, et al. Diphenyleneiodonium chloride, an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish. Biol Pharm Bull. 2011;34(8):1343-7.
[3] Suzuki H, Hatano N, Muraki Y, Itoh Y, Kimura S, Hayashi H, Onozaki K, Ohi Y, Haji A, Muraki K. The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor. Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C384-94.
[4] Park SE, Song JD, Kim KM, Park YM, Kim ND, Yoo YH, Park YC. Diphenyleneiodonium induces ROS-independent p53 expression and apoptosis in human RPE cells. FEBS Lett. 2007 Jan 23;581(2):180-6.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1792 mL
- 15.8958 mL
- 31.7915 mL
- 5 mM
- 0.6358 mL
- 3.1792 mL
- 6.3583 mL
- 10 mM
- 0.3179 mL
- 1.5896 mL
- 3.1792 mL

技术信息

CAS号

4673-26-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H8ClI

运输

蓝冰

分子量

314.55

别名

DPI;Diphenyleneiodonium (chloride);Diphenyleneiodonium Chloride;Dibenziodolium chloride

溶解度

DMSO	13.0 mg/mL (41.3 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

3% DMSO+40% PEG 300+2% Tween 80+water

0.5 mg/mL

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

氯化二亚苯基碘鎓 Catalog No. CSN20629

靶点选择性

请登录您的专属账户

确认信息