|(3-氨基-3-羧丙基)二甲基氯化锍|CsnPharm

CAS No.: 3493-12-7

DL-Methionine Methylsulfonium Chloride/维生素U Catalog No. CSN21439

Synonyms: DL-蛋氨酸甲基氯化锍

DL-Methionine Methylsulfonium Chloride (DL-MMSC) is a vitamin found in green vegetables with therapeutic effect on peptic ulcers, colitis, and gastritis. It is also used as a methionine analogue.

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实验方案

技术信息

生物活性

描述DL-methionine methylsulfonium chloride is a naturally occurring methionine derivative. DL-methionine methylsulfonium chloride protects gastric mucosal from ethanol-induced damage. One milliliter of 1, 2, or 5% DL-cysteine (cysteine) or DL-methionine methylsulfonium chloride (MMSC) was instilled into the rat stomach 1, 24, and 48 h after giving ethanol (1 mL of 40% solution) by gavage. One hour following the administration of ethanol, gastric mucosal injury was seen in all the animals. Treatment with 2% cysteine or MMSC significantly (p less than 0.01) reduced the extent of this injury^[1]. Gavage with 1% DL-cysteine or DL-methionine-S-methylsulfonium chloride at 1 mL/day for 2 weeks and 5 days protected against ulceration in 30% of the rats, and this protection extended to 80% of cases with 2% solutions. Similar gavage with 5% solutions protected all rats against ulceration without significantly influencing the basal H+ output [13.1 +/- 0.3 and 14.2 +/- 0.2 mumol for DL-cysteine and DL-methionine-S-methylsulfonium chloride, respectively, versus 15.1 +/- 0.4 mumol (mean +/- standard error of the mean; n = 10)]; that is, cytoprotection was achieved^[2].
参考文献

[1] Salim AS. Role of sulfhydryl-containing agents in the healing of erosive gastritis and chronic gastric ulceration in the rat. J Pharm Sci. 1992 Jan;81(1):70-3
[2] Salim AS. Protection against chronic gastric ulceration in the rat with sulfhydryl-containing agents. J Pharm Sci. 1992 Jul;81(7):698-700

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.0075 mL
- 25.0377 mL
- 50.0754 mL
- 5 mM
- 1.0015 mL
- 5.0075 mL
- 10.0151 mL
- 10 mM
- 0.5008 mL
- 2.5038 mL
- 5.0075 mL

技术信息

CAS号

3493-12-7

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C6H14ClNO2S

运输

蓝冰

分子量

199.70

别名

DL-蛋氨酸甲基氯化锍

溶解度

DMSO	insoluble
Water	250.0 mg/mL (1251.9 mM)

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