|2,3-二甲氧基-1,4-萘醌|CsnPharm

CAS No.: 6956-96-3

DMNQ Catalog No. CSN24748

Synonyms: NSC 69355

DMNQ is a 1,4-naphthoquinone with redox cycling property. It increases the formation of superoxide and hydrogen peroxide in cells.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述DMNQ is a 1,4-naphthoquinone with redox cycling property. It increases the formation of superoxide and hydrogen peroxide in cells^[1]. The release of lactate dehydrogenase in rat hepatocytes was induced by a 5-h incubation with DMNQ (60 – 200μM) in a dose-dependent manner and reached 80% at the dosage of 200μM. Treatment of hepatocytes with 60 μM DMNQ significantly increased the production of superoxide anion compared to untreated group. DMNQ at the same dosage also decreased the levels of reduced glutathione and glutathione disulfide by 62% and 76%, respectively, in hepatocytes. The addition of 60 μM DMNQ to rat liver microsomal suspension led to a significant increase in NADPH oxidation^[2]. In a mouse model of Huntington's Disease, the exposure of 1mM DMNQ for 90 min induced mitochondrial damage, while administration of XJB-5-131 and DMNQ together recovered mitochondrial spare respiratory capacity and increased oxygen consumption rate in these animals^[3].
作用机制DMNQ is a non-thiol-capturing and non- alkylating redox cycler that generates superoxide and hydrogen peroxide.
参考文献

[1] Klotz LO, Hou X, Jacob C. 1,4-naphthoquinones: from oxidative damage to cellular and inter-cellular signaling. Molecules. 2014 Sep 17;19(9):14902-18. doi: 10.3390/molecules190914902. PMID: 25232709; PMCID: PMC6270801.
[2] Ishihara Y, Shiba D, Shimamoto N. Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition. Toxicol Appl Pharmacol. 2006 Jul 15;214(2):109-17. doi: 10.1016/j.taap.2005.12.003. Epub 2006 Jan 20. PMID: 16430935.
[3] Xun Z, Rivera-Sánchez S, Ayala-Peña S, Lim J, Budworth H, Skoda EM, Robbins PD, Niedernhofer LJ, Wipf P, McMurray CT. Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Rep. 2012 Nov 29;2(5):1137-42. doi: 10.1016/j.celrep.2012.10.001. Epub 2012 Nov 1. PMID: 23122961; PMCID: PMC3513647.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.5828 mL
- 22.9142 mL
- 45.8284 mL
- 5 mM
- 0.9166 mL
- 4.5828 mL
- 9.1657 mL
- 10 mM
- 0.4583 mL
- 2.2914 mL
- 4.5828 mL

技术信息

CAS号

6956-96-3

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H10O4

运输

蓝冰

分子量

218.21

别名

NSC 69355

溶解度

DMSO	24.0 mg/mL (110.0 mM)
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

DMNQ Catalog No. CSN24748

靶点选择性

请登录您的专属账户

确认信息