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CAS No.: 34221-41-5

Echinatin/刺甘草查尔酮 Catalog No. CSN19432

Synonyms: Retrochalcone;刺甘草查尔酮

Echinatin, a natural product isolated and purified from the root of Glycyrrhiza glabra L.

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技术信息

生物活性

描述Echinatin is a chalcone isolated from the Chinese herbal medicine Gancao with hepatoprotective and anti-inflammatory effects^[3]. Administration of echinatin obviously inhibits NLRP3 inflammasome activation and ameliorates LPS-induced septic shock and dextran sodium sulfate-induced (DSS-induced) colitis in mice. Moreover, echinatin exerted favorable pharmacological effects on liver inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis (NASH)^[4]. Echinatin induced apoptosis and autophagy through inactivation of AKT/mTOR signaling pathway, whereas constitutive activation of AKT significantly abrogated these effects. Furthermore, echinatin had a significant antitumor effect in the tumor xenograft model and markedly suppressed cell migration and invasion abilities of ESCC (Esophageal squamous cell carcinoma) cells in a dose-dependent manner^[5]. Echinatin exerted its protective effect against MI/R (myocardial ischemic/reperfusion) injury at least partially by suppressing the Hippo/YAP signaling pathway^[6]. Echinatin mitigates H2O2-induced oxidative damage and apoptosis in HLECs (Human lens epithelial B3 cells) via the Nrf2/HO-1 pathway, suggesting that Ech may be a potential drug for the treatment of cataracts^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6999 mL
- 18.4993 mL
- 36.9987 mL
- 5 mM
- 0.7400 mL
- 3.6999 mL
- 7.3997 mL
- 10 mM
- 0.3700 mL
- 1.8499 mL
- 3.6999 mL

技术信息

CAS号

34221-41-5

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H14O4

运输

蓝冰

分子量

270.28

别名

Retrochalcone;刺甘草查尔酮

溶解度

DMSO	53.0 mg/mL (196.1 mM)
Water	Insoluble
Ethanol	27.0 mg/mL (99.9 mM)

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