|(3S,6S,9S,12S,15S,18S)-3-((1H-咪唑-4-基)甲基)-18-((1H-吲哚-3-基)甲基)-1-((1R,4S,7S,10S,13S,16S,19S,22S,25R,28S,31R,36R,39R,42S,45S)-31-氨基-7-(4-氨丁基)-39-苄基-4-(2-羧乙基)-10-(羧甲基)-42-(4-羟基苄基)-19,22,28-三(羟甲基)-16-异丁基-45-异丙基-13-(2-(甲硫基)乙基)-3,6,9,12,15,18,21,24,27,30,38,41,44,47-十四氧代-33,34,49,50-四硫杂-2,5,8,11,14,17,20,23,26,29,37,40,43,46-十四氮杂双环[23.22.4]五十一烷-36-基)-12,15-二((S)-仲丁基)-9-(羧甲基)-6-异丁基-1,4,7,10,13,16-六氧代-2,5,8,11,14,17-六氮杂十九烷-19-酸|CsnPharm

CAS No.: 117399-94-7

Endothelin 1 (swine, human)/内皮缩血管肽 1 (猪,人) Catalog No. CSN21629

Synonyms: Endothelin 1 (swine;human);内皮缩血管肽 1 (猪,人

Endothelin 1 (human, porcine) is a peptide vasoconstrictor and agonist of endothelin (ET) receptors ETA and ETB.

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400-920-2911

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技术信息

生物活性

描述Endothelin-1 (ET-1) is a potent vasoconstrictor peptide isolated from porcine endothelial cells^[1]. Endothelin-1 (ET-1) is an astrocyte-derived signal that regulates oligodendrocyte progenitor cells (OPC) migration and differentiation. OPCs In vivo and in culture express functional ET(A) and ET(B) receptors, which mediate ET-1-induced ERK (extracellular signal-regulated kinase) and CREB (cAMP response element-binding protein) phosphorylation. ET-1 exerts both chemotactic and chemokinetic effects on OPCs to enhance cell migration; it also prevents lineage progression from the O4(+) to the O1(+) stage without affecting cell proliferation^[2]. ET-1 significantly increased DNA synthesis in the cells. These biological actions were induced by ET-1, probably via a cAMP-protein kinase A pathway and intracellular calcium mobilization-protein kinase C pathway^[3]. In the heart, ET-1 also causes positive inotropic and chronotropic responses and hypertrophic activity of the cardiomyocytes. ETs act via activation of two receptor subtypes, ETA and ETB receptors, both of which are coupled to various GTP-binding proteins depending on cell types^[4]. The endothelin-1-induced contraction of retinal arteries is dependent on an influx of extracellular Ca2+ through membrane potential-operated calcium channels. Endothelin-1, 10^-13-10^-10 M, did not induce a relaxation of endothelium-intact arteries, indicating that endothelin-1 is incapable of releasing endothelium-derived relaxing factor in the retinal circulation^[5]. ET-1-induced activation of PI3K/AKT is dependent on p38 mitogen-activated protein kinase (MAPK), but not extracellular signal-regulated kinase (ERK) 1/2, JNK, or transforming growth factor (TGF)-beta1. Activation of the PI3K/AKT pathway by ET-1 inhibits fibroblast apoptosis, and this inhibition is reversed by blockade of p38 MAPK or PI3K^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.4013 mL
- 2.0065 mL
- 4.0130 mL
- 5 mM
- 0.0803 mL
- 0.4013 mL
- 0.8026 mL
- 10 mM
- 0.0401 mL
- 0.2006 mL
- 0.4013 mL

技术信息

CAS号

117399-94-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C109H159N25O32S5

运输

蓝冰

分子量

2491.90

别名

Endothelin 1 (swine;human);内皮缩血管肽 1 (猪,人

溶解度

Water

50.0 mg/mL (20.1 mM) warming

动物实验配方

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Endothelin 1 (swine, human)/内皮缩血管肽 1 (猪,人) Catalog No. CSN21629

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