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CAS No.: 501921-61-5

Entasobulin Catalog No. CSN23677

Synonyms: UNIITB77GU6BFO. Pubchem SID 175427608

Entasobulin is an inhibitor of β-tubulin polymerization with antineoplastic activity.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Microtubules (MTs) are highly dynamic structures that perform diverse and critical functions in cell structure, cell division, motility, and signal transduction. MTs are composed of soluble tubulin subunits comprising α- and β-tubulins. The formation of MTs reflects the balance between polymerization and de-polymerization of α/β-tubulin heterodimers. The tubulin polymerization assay has already been a powerful tool in characterizing the interactions between drugs and MTs^[1]. Entasobulin, an indolizine-glyoxylamide based small molecule, is an inhibitor for β-tubulin polymerization with anti-proliferative activities over cancer cell lines, including multidrug resistance (MDR) phenotypes.
参考文献

[1] Liu C, Yao J, Yin J, Xue J, Zhang H. Recombinant α- and β-tubulin from Echinococcus granulosus: expression, purification and polymerization. Tubulines α et β recombinantes d’Echinococcus granulosus : expression, purification et polymérisation. Parasite. 2018;25:62

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2733 mL
- 11.3665 mL
- 22.7330 mL
- 5 mM
- 0.4547 mL
- 2.2733 mL
- 4.5466 mL
- 10 mM
- 0.2273 mL
- 1.1366 mL
- 2.2733 mL

技术信息

CAS号

501921-61-5

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H18ClN3O2

运输

蓝冰

分子量

439.89

别名

UNIITB77GU6BFO. Pubchem SID 175427608

溶解度

DMSO	108.0 mg/mL (245.5 mM)
Water	insoluble

动物实验配方

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