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CAS No.: 93-28-7

Eugenol acetate/乙酸丁香酚酯 Catalog No. CSN23540

Synonyms: Eugenyl acetate;Acetyleugenol;NSC-1242

Eugenol acetate, a flavouring agent, can reduce cell proliferation with antibacterial and anti-virulence activities. It is found in caraway, the oil of clove, cinnamon leaf and other essential oils.

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技术信息

生物活性

描述Eugenol acetate (EA,Eugenyl acetate), a major phytochemical constituent of the essential oil exhibits antibacterial, antioxidant, and anti-virulence activities. Minimum inhibitory concentrations (MIC) of EA against Candida isolates were in the range between 0.1% and 0.4% (v/v). The compound at sub-MIC (0.0125% v/v) significantly inhibited serum-induced germ tube formation by C. albicans. Eugenyl acetate inhibited biofilm forming ability of the organisms as well as reduced the adherence of Candida cells to HaCaT keratinocytes cells. In addition, upon treatment with EA, the phagocytic activity of macrophages was increased significantly against C. albicans^[1]. Eugenyl acetate at 150 µg/ml, significantly inhibited virulence factor production such as pyocyanin and pyoverdin by Pseudomonas aeruginosa ATCC 27853 up to 9.4 (P < 0.01) and 3.7 fold (P < 0.01), respectively. In addition, protease activity of P. aeruginosa was significantly reduced upon treatment with EA. The test compound (150 µg/ml) lowered haemolytic activity of Staphylococcus aureus ATCC 29213 up to tenfold ^[2].
参考文献

[1] Musthafa KS, Hmoteh J, Thamjarungwong B, Voravuthikunchai SP. Antifungal potential of eugenyl acetate against clinical isolates of Candida species. Microb Pathog. 2016;99:19‐29
[2] Musthafa KS, Voravuthikunchai SP. Anti-virulence potential of eugenyl acetate against pathogenic bacteria of medical importance. Antonie Van Leeuwenhoek. 2015;107(3):703‐710

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.8487 mL
- 24.2436 mL
- 48.4872 mL
- 5 mM
- 0.9697 mL
- 4.8487 mL
- 9.6974 mL
- 10 mM
- 0.4849 mL
- 2.4244 mL
- 4.8487 mL

技术信息

CAS号	93-28-7	储存条件	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C12H14O3	运输	蓝冰
分子量	206.24	别名	Eugenyl acetate;Acetyleugenol;NSC-1242;Eugenol Acetate;乙酸丁香酚酯;丁香酚乙酸酯

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