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CAS No.: 1219739-36-2

EX229 Catalog No. CSN21095

Synonyms: AMPK Activator 991;compound 991

Novel AMPK activator, increasing AMPK activity of both AMPKgamma1- and AMPKgamma3-containing complexes in mouse skeletal muscle

规格	价格	促销价格	库存	数量

400-920-2911

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tech@csnpharm.cn

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance by sensing and responding to increases in AMP/ADP concentration relative to ATP ^[1]. EX229, a benzimidazole derivative, is a potent and allosteric activator of AMPK, with K_ds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1, respectively ^[1]. EX229 increases phosphorylation of endogenous AMPK Thr-172 (pT172) and the AMPK target ACC (pACC) in HEK293 cells ^[2].
作用机制EX229 binds in a pocket generated at the interface between the CBM (carbohydrate-binding module) and the kinase domain, and makes interactions with a cluster of hydrophobic residues from each domain ^[1].
参考文献

[1] Xiao B. Structural basis of AMPK regulation by small molecule activators. Nat Commun. 2013;4:3017. doi: 10.1038/ncomms4017.
[2] Xiao B. Structural basis of AMPK regulation by small molecule activators. Nat Commun. 2013;4:3017. doi: 10.1038/ncomms4017.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3155 mL
- 11.5775 mL
- 23.1551 mL
- 5 mM
- 0.4631 mL
- 2.3155 mL
- 4.6310 mL
- 10 mM
- 0.2316 mL
- 1.1578 mL
- 2.3155 mL

技术信息

CAS号

1219739-36-2

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H18ClN3O3

运输

蓝冰

分子量

431.87

别名

AMPK Activator 991;compound 991

溶解度

DMSO	60.0 mg/mL (138.9 mM)
Water	insoluble

动物实验配方

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