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CAS No.: 125256-00-0

Fatostatin/脂肪抑制素 Catalog No. CSN19276

Synonyms: 125B11;Fatostatin-A

Fatostatin A is an inhibitor of SREBP that directly binds SCAP and blocks its ER-to-Golgi transport with IC50 of 2.5 and 10 μM in mammalian cells.

规格	价格	促销价格	库存	数量

400-920-2911

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技术信息

生物活性

描述Fatostatin is an inhibitor of SREBP that directly binds SCAP (SREBP cleavage-activating protein) and blocks its ER-to-Golgi transport with IC50 of 2.5 and 10 μM in mammalian cells. Fatostatin blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake^[3]. In vitro analysis revealed that fatostatin significantly inhibited the secretion of inflammatory cytokines from cells activated with lipopolysaccharide, without affecting cell viability^[4]. Fatostatin inhibited tubulin polymerization, arrested cells in mitosis, activated the spindle assembly checkpoint, and triggered mitotic catastrophe and reduced cell viability^[5]. Fatostatin, an inhibitor of SREBP1, could increase the sensitivity of endometrial cancer to progesterone and reverse progesterone resistance by inhibiting SREBP1 both in vitro and in vivo^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3966 mL
- 16.9829 mL
- 33.9658 mL
- 5 mM
- 0.6793 mL
- 3.3966 mL
- 6.7932 mL
- 10 mM
- 0.3397 mL
- 1.6983 mL
- 3.3966 mL

技术信息

CAS号

125256-00-0

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H18N2S

运输

蓝冰

分子量

294.41

别名

125B11;Fatostatin-A

溶解度

DMSO	20.5 mg/mL (69.6 mM)
Water	insoluble

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Fatostatin/脂肪抑制素 Catalog No. CSN19276

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