|(S)-1-((3S,6S,9S,12S,18S,21S)-3-((1H-咪唑-5-基)甲基)-6-((1H-吲哚-3-基)甲基))-21-(3-胍基丙基)-12-(4-羟基苄基)-9-(羟甲基)-18-异丁基-1,4,7,10,13,16,19-七氧代-1-((S)- 5-氧代吡咯烷-2-基)-2,5,8,11,14,17,20-七氮杂二十二烷-22-酰基)-N-乙基吡咯烷-2-甲酰胺|CsnPharm

CAS No.: 38234-21-8

Fertirelin/夫替瑞林 Catalog No. CSN11007

Synonyms: 夫替瑞林

Fertirelin is an analog of gonadotropin-releasing hormone agonist .

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Gonadotropin-releasing-hormone (GnRH) analogues are synthetic compounds derived from decapeptide neurohormones (LHRH; LH/FSH-RH). They have a key role in hormone dependent cancer, particularly breast and prostate cancer(i.e. ovariectomy and orchiectomy), providing an androgen and estrogen ablation. GnRH exert an inhibitory action on the growth of hormone-dependent human and canine mammary tumor^[3]. The GnRH receptor rather interacts with the mitogenic signal transduction of growth-factor receptors and related oncogene products associated with tyrosine kinase activity via activation of a phosphotyrosine phosphatase resulting in downregulation of cancer cell proliferation^[4]. GnRH analogues counteract the proliferating effects of both epidermal growth factor (EGF) and insulin like growth factor (IGF-I); additionally, it affects the mitogen-activated protein kinase (MAPK) cascade and modulates the activity of the urokinase-type plasminogen activator (uPA)/plasminogen activator inhibitory (PAI) system, which is involved in the process of metastasis^[5]. Fertirelin, an analog of GnRH 2.5 to 10 times more potent than native GnRH, has become the treatment of choice for reversing follicular cysts^[6]. Administration of high doses of Fertirelin is found to reduce superovulatory responses^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.8671 mL
- 4.3354 mL
- 8.6708 mL
- 5 mM
- 0.1734 mL
- 0.8671 mL
- 1.7342 mL
- 10 mM
- 0.0867 mL
- 0.4335 mL
- 0.8671 mL

技术信息

CAS号

38234-21-8

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C55H76N16O12

运输

蓝冰

分子量

1153.29

别名

夫替瑞林

溶解度

DMSO	95.0 mg/mL (82.4 mM) warming
Water	100.0 mg/mL (86.7 mM) warming

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Fertirelin/夫替瑞林 Catalog No. CSN11007

靶点选择性

请登录您的专属账户

确认信息