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CAS No.: 1847-24-1

Flucloxacillin sodium/氟氯西林钠 Catalog No. CSN23817

Synonyms: floxacillin sodium;Flucloxacillin;Floxacillin

Flucloxacillin Sodium is a narrow-spectrum beta-lactam antibiotic of the penicillin class, used to treat infections caused by susceptible Gram-positive bacteria.

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技术信息

生物活性

描述Flucloxacillin sodium is a highly active antibiotic against Gram-positive and Gram-negative bacteria. The serum elimination half-life of flucloxacillin is 1.31-1.39 hours, and six hours after administration of a single 250 mg dose the serum concentration of flucloxacillin is 0.46 mg/mL^[1]. Oral flucloxacillin does not affect sweat electrolytes and is not a contraindication to sweat testing^[2]. Flucloxacillin has been reported to be metabolized in man to the penicilloic acid, the antibacterially active 5'-hydroxymethyl derivative and the penicilloic acid of the 5'-hydroxymethyl derivative. The metabolism of flucloxacillin in the rat is similar^[3]. Flucloxacillin (FLU) was designed for oral and injectable administration with bactericidal activity. FLU sodium is the form used in pharmaceutical formulations. It is an antimicrobial resistant against penicillinase, an enzyme responsible for cleaving the beta-lactam ring of penicilins, which leads to inactivity of the drug^[4].
参考文献

[1] Paton DM, Mander P, Avery RJ. Bioavailability and half-life of two preparations of flucloxacillin. N Z Med J. 1982;95(719):766-768
[2] Williams J, Griffiths PD, Green A, Weller PH. Sweat tests and flucloxacillin. Arch Dis Child. 1988;63(7):847-848
[3] Everett JR, Jennings K, Woodnutt G. 19F NMR spectroscopy study of the metabolites of flucloxacillin in rat urine. J Pharm Pharmacol. 1985;37(12):869-873
[4] Menezes MN, de Marco BA, Fiorentino FAM, Zimmermann A, Kogawa AC, Salgado HRN. Flucloxacillin: A Review of Characteristics, Properties and Analytical Methods. Crit Rev Anal Chem. 2019;49(1):67-77

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1015 mL
- 10.5075 mL
- 21.0150 mL
- 5 mM
- 0.4203 mL
- 2.1015 mL
- 4.2030 mL
- 10 mM
- 0.2102 mL
- 1.0508 mL
- 2.1015 mL

技术信息

CAS号

1847-24-1

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H16ClFN3NaO5S

运输

蓝冰

分子量

475.85

别名

floxacillin sodium;Flucloxacillin;Floxacillin;Floxapen;Fluorochloroxacillin;氟氯西林钠

溶解度

DMSO	94.0 mg/mL (197.5 mM)
Water	93.0 mg/mL (195.4 mM)
Ethanol	5.0 mg/mL (10.5 mM)

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Flucloxacillin sodium/氟氯西林钠 Catalog No. CSN23817

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