|7-氯-1-环丙基-6-氟-4-氧-1,4-二氢喹啉-3-羧酸|CsnPharm

CAS No.: 86393-33-1

Fluoroquinolonic Acid/7-氯-1-环丙基-6-氟-1,4-二氢-4-氧代喹啉-3-羧酸 Catalog No. CSN23600

Synonyms: Ciprofloxacin Impurity A;Q-Acid;Fluoroquinolonic acid

Fluoroquinolonic acid acts as an intermediate during the synthesis of ciprofloxacin HCl which is a broad-spectrum antibacterial agent.

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技术信息

生物活性

描述Fluoroquinolonic Acid is an antibacterial agents. Conjugation of fluoroquinolones with substitutions such as 1,2,4-triazoles, alkyl oximes, flavonoids, aryl furans, benzofuroxans, metronidazoles or even other antibiotics such as neomycin-B produced derivatives that have a superior and wider spectrum of activity and better resistance than the classical fluoroquinolone agents. Addition of a hydroxamic acid moiety to fluoroquinolones also increased the activity against Proteus mirabilis, which represents one of the most resistant strains of bacteria in urinary tract infections^[1]. Fluoroquinolones and propionic acid derivatives that are structurally related to levofloxacin and loxoprofen, respectively, were also found to induce immune-related gene expression in HL-60 cells^[2]. A well-described and serious adverse event associated with receipt of fluoroquinolones is tendinitis and tendon rupture^[3].
参考文献

[1] Ezelarab HAA, Abbas SH, Hassan HA, Abuo-Rahma GEA. Recent updates of fluoroquinolones as antibacterial agents. Arch Pharm (Weinheim). 2018;351(9):e1800141
[2] Nakajima A, Sato H, Oda S, Yokoi T. Fluoroquinolones and propionic acid derivatives induce inflammatory responses in vitro. Cell Biol Toxicol. 2018;34(1):65‐77
[3] Bidell MR, Lodise TP. Fluoroquinolone-Associated Tendinopathy: Does Levofloxacin Pose the Greatest Risk?. Pharmacotherapy. 2016;36(6):679‐693

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5503 mL
- 17.7513 mL
- 35.5025 mL
- 5 mM
- 0.7101 mL
- 3.5503 mL
- 7.1005 mL
- 10 mM
- 0.3550 mL
- 1.7751 mL
- 3.5503 mL

技术信息

CAS号

86393-33-1

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H9ClFNO3

运输

蓝冰

分子量

281.67

别名

Ciprofloxacin Impurity A;Q-Acid;Fluoroquinolonic acid;氟喹诺酸

溶解度

DMSO	24.0 mg/mL (85.2 mM)

动物实验配方

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Fluoroquinolonic Acid/7-氯-1-环丙基-6-氟-1,4-二氢-4-氧代喹啉-3-羧酸 Catalog No. CSN23600

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