CAS No.: 821794-92-7
FMK Catalog No. CSN15722
Synonyms: Fluoromethyl Ketone;Fluoromethyl Ketone-MEA;FMK-MEA
FMK is an an irreversible RSK2 kinase inhibitor, that covalently modifies the C-terminal kinase domain of RSK.
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纯度 & 质量文件
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靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03699332 Peritoneal Carcinomatosis ... more >> Colorectal Cancer Carcinoma Neoplasms Gastrointestinal Cancer Collapse << Phase 1 Phase 2 Not yet recruiting September 2021 - NCT03460444 MCT Oil Supplementation Not Applicable Recruiting January 31, 2019 Canada, British Columbia ... more >> University of British Columbia, Okanagan. Recruiting Kelowna, British Columbia, Canada, V1V 1V7 Contact: Jonathan P Little, PHD +12508786893 jonathan.little@ubc.ca Contact: Helena Neudorf, BHK 250 807 9122 h.neudorf@alumni.ubc.ca Collapse << NCT03369652 Older Patients ... more >> Medication Review Cross-sectional Communication Collapse << Not Applicable Recruiting November 2018 Denmark ... more >> Odense University Hospital Not yet recruiting Odense, Denmark, 5000 Contact: Trine Graabæk, phd trine.graabaek.hansen2@rsyd.dk Svendborg Sygehus Recruiting Svendborg, Denmark Contact: Michelle Lyndgaard, pharmacist michelle.nielsen@rsyd.dk Collapse << - 参考文献
- [1] Cuello F, Snabaitis AK, et al. Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation. Mol Pharmacol. 2007 Mar;71(3):799-806.
- [2] Bain J, Plater L, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 821794-92-7 | 储存条件 |
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| 分子式 | C18H19FN4O2 | 运输 | 蓝冰 | |
| 分子量 | 342.37 | 别名 | Fluoromethyl Ketone;Fluoromethyl Ketone-MEA;FMK-MEA;RSK2 Kinase Inhibitor;Fmk |
