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CAS No.: 1025687-58-4
Synonyms: R788(Disodium);R-788;Prodrug of R406
R788 disodium, the disodium form of R788, is a Syk inhibitor with IC50 of 41 nM.
生物活性
靶点 | Syk IC50:41nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT02612558 | Warm Antibody Autoimmune Hemol... more >>ytic Anemia Collapse << | Phase 2 | Active, not recruiting | June 2019 | - |
NCT00665925 | Rheumatoid Arthritis | Phase 2 | Completed | - | - |
NCT00665626 | Rheumatoid Arthritis | Phase 2 | Completed | - | - |
实验方案
技术信息
CAS号 | 1025687-58-4 | 储存条件 |
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分子式 | C23H24FN6Na2O9P | 运输 | 蓝冰 | |||||||||
分子量 | 624.42 | 别名 | R788(Disodium);R-788;Prodrug of R406;R788 (sodium salt);Fostamatinib;NSC 745942;Tamatinib Fosdium;R-935788;R-788 sodium. R935788 sodium. Fostamatinib sodium;Fostamatinib disodium hexahydrate;福他替尼二钠盐;R788(Disodium | |||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human Ramos cells | - | Cytotoxic assay | - | Cytotoxicity against human Ramos cells, IC50=0.267 μM | 23151054 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT02612558 | Warm Antibody Autoimmune Hemol... more >>ytic Anemia Collapse << | Phase 2 | Active, not recruiting | June 2019 | - |
NCT00665925 | Rheumatoid Arthritis | Phase 2 | Completed | - | - |
NCT00665626 | Rheumatoid Arthritis | Phase 2 | Completed | - | - |
NCT00665626 | - | - | Completed | - | - |
NCT00752999 | Systemic Lupus Erythematosus | Phase 2 | Withdrawn(Study was withdrawn ... more >>for business reasons before study start.) Collapse << | March 2010 | - |
NCT03363334 | - | - | - | - | - |
NCT02076412 | Immune Thrombocytopenic Purpur... more >>a Collapse << | Phase 3 | Completed | - | - |
NCT02433236 | IGA Nephropathy | Phase 2 | Withdrawn(Study withdrawn prio... more >>r to enrollment of first subject) Collapse << | - | - |
NCT00665925 | - | - | Completed | - | - |
NCT02076399 | Immune Thrombocytopenic Purpur... more >>a Collapse << | Phase 3 | Completed | - | - |
NCT02077192 | Immune Thrombocytopenic Purpur... more >>a Collapse << | Phase 3 | Active, not recruiting | March 2020 | - |
NCT00706342 | - | - | Completed | - | - |
NCT00706342 | Purpura, Thrombocytopenic, Idi... more >>opathic Collapse << | Phase 2 | Completed | - | United States, New York ... more >> Research Site New York, New York, United States, 10065 United States, Ohio Research Site Cleveland, Ohio, United States, 44195 Collapse << |
靶点 | Description | IC50 |
---|---|---|
Syk | IC50:41nM |
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