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CAS No.: 1426138-42-2

FX1 Catalog No. CSN22317

Synonyms: FX1

FX1 is a BCL6 inhibitor that effectively blocks BCL6 N-terminal BTB domain-mediated corepressors chromosome recruitment (by 61-87%/SMRT and 67-82%/BCOR; 50 μM FX1 for 30 min) and selectively suppresses BCL6-depenent growth (GI50 16-54 μM; >125 μM against BCL6-independent cells) in diffuse large B cell lymphoma (DLBCL) cultures, exhibiting greater affinity than its structure analog 79-6 or BCL6 corepressor SMRT for BTB domain (KD = 7 μM/FX1, 30 μM/SMRT, 129 μM/79-6). FX1 shows greater efficacy than 79-6 in reversing BCL6/corepressors-mediated target genes repression in vitro (IC50 = 35 μM vs. 318 μM with 79-6 by HEK293T-based reporter assay) and in suppressing OCI-Ly7 DLBCL xenograft tumor growth mice in vivo (100% vs. 45% suppression with respective compound via 25 mg/kg/day i.p.).

规格 价格 促销价格 库存 数量
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靶点选择性

生物活性

实验方案

技术信息

CAS号 1426138-42-2 储存条件
分子式 C14H9ClN2O4S2 运输 蓝冰
分子量 368.82 别名 FX1
溶解度
DMSO72.0 mg/mL (195.2 mM)
WaterInsoluble
EthanolInsoluble
动物实验配方

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