|2-(4-氯苯基)-6-硝基-1H-苯并[d]咪唑|CsnPharm

CAS No.: 1571-87-5

Synonyms: 2-(4-Chlorophenyl)-5-nitrobenzimidazole;PPK1-IN-8;NSC657185

GABAA receptor agent 1 is a high affinity ligand for GABAA receptor, with potent anticonvulsant activity.

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400-920-2911

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400-920-2911

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描述GABAA receptor agent 1 is a high affinity ligand for GABAA receptor, with potent anticonvulsant activity. GABAA receptor agent 1 (30 mg/kg; intraperitoneal) inhibits the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions in swiss albino rats^[1]. The GABAA receptor is a multimeric membrane-spanning ligand-gated ion channel that admits chloride upon binding of the neurotransmitter GABA and is modulated by many endogenous and therapeutically important agents. The GABAA receptor is virtually the only site of action for the centrally acting benzodiazepines, the most widely prescribed of the anti-anxiety medications^[2]. The GABAA receptor plays a key role in mediating the synergistic effects of 5-HT1A and σ1 receptor activation on prefrontal dopamine neurotransmission^[3]. 5-HT2C receptors inhibit GABAA receptors by a Ca(2+)-dependent, but phosphorylation independent, mechanism and that 5-HT and GABA may act as cotransmitters to regulate neuronal activity^[4].
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CAS号	1571-87-5	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C13H8ClN3O2	运输	蓝冰
分子量	273.67	别名	2-(4-Chlorophenyl)-5-nitrobenzimidazole;PPK1-IN-8;NSC657185

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