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CAS No.: 568-80-9

Galloflavin Catalog No. CSN33152

Synonyms: NSC 107022

Galloflavin is an inhibitor of both LDH-A and -B with Ki values of 5.46 μM (LDH-A) and 15.06 μM (LDH-B), respectively. It inhibits both human LDH isoforms by preferentially binding the free enzyme, without competing with the substrate or cofactor.

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描述Lactate dehydrogenase (LDH) is an essential metabolic enzyme that catalyzes the interconversion of pyruvate and lactate using NADH/NAD(+) as a co-substrate. Many cancer cells exhibit a glycolytic phenotype known as the Warburg effect, in which elevated LDH levels enhance the conversion of glucose to lactate, making LDH an attractive therapeutic target for oncology^[1]. Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 µM and 15.06 µM, respectively. Galloflavin is also a potential anticancer agent^[2]. Galloflavin and Ellagic acid showed anti-proliferative effects on Caco2. The compounds also upregulated SIRT6 expression whereas key proteins in glycolysis were downregulated. Galloflavin decreased glucose transporter 1 (GLUT1) expression, and Ellagic acid affected the expression of protein dehydrogenase kinase 1 (PDK1)^[3]. Galloflavin reduced PDAC proliferation in monoculture (P < 0.01); however, in co-culture with PSCs, an antiproliferative effect was only evident in PANC-1 (P = 0.001). An apoptotic effect was observed in MIA PaCa-2 and BxPC-3 in coculture (P < 0.05). A reduction in media lactate was observed in coculture (P < 0.01) with PSCs. Immunohistochemistry revealed stromal and tumoral LDHB expression had no impact on survival^[4].Galloflavin effectively inhibited cell growth in endometrial cancer cell lines and primary cultures of human endometrial cancer through its involvement in multiple signaling pathways that regulate metabolism, cell cycle, apoptosis, cell stress and metastasis^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5949 mL
- 17.9745 mL
- 35.9491 mL
- 5 mM
- 0.7190 mL
- 3.5949 mL
- 7.1898 mL
- 10 mM
- 0.3595 mL
- 1.7975 mL
- 3.5949 mL

技术信息

CAS号	568-80-9	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C12H6O8	运输	蓝冰
分子量	278.17	别名	NSC 107022

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