|(2S,3R,4S,5S,6R)-2-(((S)-2-((3S,5R,8R,9R,10R,12R,13R,14R,17S)-3,12-二羟基-4,4,8,10,14-五甲基十六氢-1H-环戊二稀并[a]菲-17-基)-6-甲基庚-5-烯-2-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇|CsnPharm

CAS No.: 39262-14-1

Ginsenoside C-K/人参皂苷 CK Catalog No. CSN15653

Synonyms: Ginsenoside compound K;Ginsenoside K;人参皂苷 C-K

Ginsenoside CK, a natural product isolated and purified from the roots of Panax ginseng C.A.Mey., is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A.

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生物活性

描述Ginsenoside CK is one of the intestinal bacterial metabolites of ginsenoside prototype saponins. Ginsenoside CK effectively prevented TGF-β-induced EMT, as indicated by the upregulation of E-cadherin and downregulation of vimentin. Furthermore, ginsenoside CK inhibited the metastatic ability of A549 cells in the tail vein lung metastasis model of nude mice^[3]. CK (Ginsenoside CK) inhibited viability and proliferation, induced apoptosis, and inhibited the migration and invasion of osteosarcoma cells through the PI3K/mTOR/p70S6K1 signaling pathway^[4]. The oral delivery of ginsenoside CK could inhibit the growth of xenograft tumors and block HIF-1α and NF-κB signaling as well as EMT (Epithelial-mesenchymal transformation) marker expression^[5]. CK pretreatment promoted cell viability and attenuated ROS accumulation and intracellular mitochondrial damage induced by I/R injury Moreover, CK reduced autophagy by regulating the formation of phagocytic precursors to autophagosomes and also inhibited apoptosis through a mitochondrial-mediated pathway. Additionally the cardioprotective effect of CK against I/R injury was mainly through the activation of the PI3K-Akt signaling pathway^[6]. Ginsenoside CK-induced apoptosis of HK-1 cells was mediated by the mitochondrial pathway and could significantly inhibit tumor growth in vivo^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03755258	Early Rheumatoid Arthritis	Phase 1	Recruiting	December 11, 2019	China, Beijing ... more >> Department of Rheumatology Recruiting Beijing, Beijing, China, 100010 Contact: Yin Su, PhD Collapse <<
NCT03136770	Pharmacokinetics	Not Applicable	Completed	-	Korea, Republic of ... more >> Seoul National University Hospital Clinical Trials Center Seoul, Korea, Republic of, 110-744 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.6055 mL
- 8.0273 mL
- 16.0546 mL
- 5 mM
- 0.3211 mL
- 1.6055 mL
- 3.2109 mL
- 10 mM
- 0.1605 mL
- 0.8027 mL
- 1.6055 mL

技术信息

CAS号	39262-14-1	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C36H62O8	运输	蓝冰
分子量	622.87	别名	Ginsenoside compound K;Ginsenoside K;人参皂苷 C-K

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