|(2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-二羟基-4,4,8,10,14-五甲基-17-((S)-6-甲基-2-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)庚烷-5-烯-2-基)十六氢-1H-环戊二烯并[a]菲-6-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-5三醇|CsnPharm

CAS No.: 22427-39-0

Ginsenoside Rg1/人参皂苷Rg1 Catalog No. CSN19481

Synonyms: Panaxoside A;Panaxoside Rg1;Ginsenoside A2

Ginsenoside Rg1, a natural product isolated and purified from the roots of Panax ginseng C. A. Mey., is a functional ligand of glucocorticoid receptor(GR) that can boost the production of insulin receptors, stimulates the creation of new blood vessels and wound healing, relaxes and widens blood vessels and lowers blood pressure, and is a potent phytoestrogen with estrogen-like activity.

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技术信息

生物活性

描述Ginsenoside Rg1, one of the most notable active components of Panax ginseng, has anti-inflammatory actions. In vitro, ginsenoside Rg1 functioned to HK-2 cells in a dose-dependent manner, and the 150 μM dose exhibited the most protective functions. Ginsenoside Rg1 protects HK-2 cells against LPS-induced inflammation and apoptosis^[3]. Moreover, ginsenoside Rg1 alleviates CS-induced pulmonary EMT in both COPD rats and HBE cells^[4]. In vivo, Ginsenoside Rg1 treatment (10 mg/mL) lameliorated depression-like behaviors and reduced chronic unpredictable mild stress exposure-Induced microglial activation and inflammatory cytokine expression within the ventral medial prefrontal cortex^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02975076	Stroke, Acute ... more >> Ischemic Attack, Transient Collapse <<	Not Applicable	Not yet recruiting	November 2019	-
NCT02316730	Healthy	Phase 1	Completed	-	China, Sichuan ... more >> West China Second University Hospital Chengdu, Sichuan, China, 610000 Collapse <<
NCT03579095	Cognitive Change ... more >> Effects of Ginseng on Cognitive Function Collapse <<	Not Applicable	Recruiting	August 14, 2018	United Kingdom ... more >> School of Psychology and Clinical Languages Recruiting Reading, United Kingdom, RG2 9JR Contact: Claire Williams, Prof 0118 378 7540 claire.williams@reading.ac.uk Contact: Adrian Whyte, PhD 0118 378 7540 a.r.whyte@reading.ac.uk Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2484 mL
- 6.2421 mL
- 12.4842 mL
- 5 mM
- 0.2497 mL
- 1.2484 mL
- 2.4968 mL
- 10 mM
- 0.1248 mL
- 0.6242 mL
- 1.2484 mL

技术信息

CAS号

22427-39-0

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C42H72O14

运输

蓝冰

分子量

801.01

别名

Panaxoside A;Panaxoside Rg1;Ginsenoside A2;Sanchinoside C1;Sanchinoside Rg1;Ginsenoside RG1;人参皂苷 Rg1

溶解度

DMSO	100.0 mg/mL (124.8 mM)

动物实验配方

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