|3-(4-((1-(反式-4-(叔丁基)环己基)-3-(4-(三氟甲氧基)苯基)脲基)甲基)苯甲酰胺基)丙酸|CsnPharm

CAS No.: 307983-31-9

GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively.

规格	价格	促销价格	库存	数量

400-920-2911

加入购物车大规格询价

产品咨询

400-920-2911

纯度 & 质量文件批次:

生物活性

描述Glucagon is the counter-regulatory hormone to insulin that promotes glucose production by stimulating glycogenolysis and gluconeogenesis. Glucagon receptor antagonists are expected to alleviate excessive, uncontrolled glucagon action. GRA Ex-25 is a glucagon receptor antagonist with IC50 values of 55 and 56nM for human and rat glucagon receptors, respectively^[2]. GRA Ex-25 moderately inhibits adenylate cyclase activity induced by glucagon with a K_i value of 254nM^[3]. The oral availability of GRA Ex-25 in rats was 17% and the in vivo t_1/2 value was 90min. Intravenous administration of rats with GRA Ex-25 at a dose of 3mg/kg significantly reduced blood glucose caused by exogenous administration of glucagon (3μg/kg)^[2].
参考文献

实验方案

技术信息

CAS号

307983-31-9

储存条件

分子式

C29H36F3N3O5

运输

蓝冰

分子量

563.61

别名

溶解度

DMSO	32.0 mg/mL (56.8 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

请登录您的专属账户