CAS No.: 1373422-53-7
GSK-J1 Catalog No. CSN13832
Synonyms: GSK-J1
GSK-J1 is a H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM for JMJD3 (KDM6B) and UTX (KDM6A), respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 作用机制
- 参考文献
- [1] Yang D, Okamura H, et al. Histone demethylase Utx regulates differentiation and mineralization in osteoblasts. J Cell Biochem. 2015 Nov;116(11):2628-36.
- [2] Kruidenier L, Chung CW, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8.
- [3] Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8
- [4] Horton JR, Engstrom A, Zoeller EL, Liu X, Shanks JR, Zhang X, Johns MA, Vertino PM, Fu H, Cheng X. Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. J Biol Chem. 2016 Feb 5;291(6):2631-46
- [5] Raeisossadati R, Móvio MI, Walter LT, Takada SH, Del Debbio CB, Kihara AH. Small Molecule GSK-J1 Affects Differentiation of Specific Neuronal Subtypes in Developing Rat Retina. Mol Neurobiol. 2019 Mar;56(3):1972-1983
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1373422-53-7 | 储存条件 |
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| 分子式 | C22H23N5O2 | 运输 | 蓝冰 | |||||
| 分子量 | 389.45 | 别名 | GSK-J1 | |||||
| 溶解度 |
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动物实验配方 |
