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CAS No.: 929095-18-1
Synonyms: GSK461364A
GSK461364 is a potent small molecule Polo-like kinase 1 (PLK1) inhibitor with a Ki of 2.2 nM.
生物活性
靶点 | PLK1 Ki:2.2nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT00536835 | Lymphoma, Non-Hodgkin | Phase 1 | Completed | - | United Kingdom ... more >> GSK Investigational Site Sutton, Surrey, United Kingdom, SM2 5PT GSK Investigational Site Belfast, Northern Ireland, United Kingdom, BT9 7AB GSK Investigational Site London, United Kingdom, W12 0NN Collapse << |
实验方案
技术信息
CAS号 | 929095-18-1 | 储存条件 |
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分子式 | C27H28F3N5O2S | 运输 | 蓝冰 | |||||||||||||
分子量 | 543.60 | 别名 | GSK461364A | |||||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human MV4-11 cells | - | Cytotoxicity assay | 24 h | Cytotoxicity against human MV4-11 cells after 24 hrs by CellTiter-Blue assay, GI50=0.679 μM | 26191363 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT00536835 | Lymphoma, Non-Hodgkin | Phase 1 | Completed | - | United Kingdom ... more >> GSK Investigational Site Sutton, Surrey, United Kingdom, SM2 5PT GSK Investigational Site Belfast, Northern Ireland, United Kingdom, BT9 7AB GSK Investigational Site London, United Kingdom, W12 0NN Collapse << |
靶点 | Description | IC50 |
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PLK1 | Ki:2.2nM |
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