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CAS No.: 341-88-8

HQNO Catalog No. CSN26126

Synonyms: 2-heptyl-4-hydroxyquinoline-N-oxide;N-oxo-2-heptyl-4-Hydroxyquinoline;KF-8940

HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa. It is a competitive inhibitor of quinone and targets the Q-site of NDH-2.

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描述Type II NADH: quinone oxidoreductase (NDH-2) is a membrane-bound bi-substrate enzyme that catalyses the cytoplasmic oxidation of NADH and reduction of quinone in the membrane. HQNO is a potent mitochondrial NDH-2 inhibitor in many species. Wide type NDH-2 had an IC₅₀ value of 10.5 ± 1.3 μM HQNO in the presence of 400 μM menadione (MD). In the presence of 50 μM MD, the IC₅₀ value for HQNO decreased slightly to 7.3 ± 1.2 μM and near complete inhibition was observed with > 50 μM HQNO^[1].
作用机制HQNO is nested into the slot-shaped tunnel of the Q-site, in which the quinone-head group is clamped by Q317 and I379 residues, and hydrogen-bonds to FAD^[1].
参考文献

[1] Petri J, Shimaki Y, Jiao W, et al. Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors. Biochim Biophys Acta Bioenerg. 2018;1859(7):482-490

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.8559 mL
- 19.2795 mL
- 38.5589 mL
- 5 mM
- 0.7712 mL
- 3.8559 mL
- 7.7118 mL
- 10 mM
- 0.3856 mL
- 1.9279 mL
- 3.8559 mL

技术信息

CAS号	341-88-8	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C16H21NO2	运输	蓝冰
分子量	259.34	别名	2-heptyl-4-hydroxyquinoline-N-oxide;N-oxo-2-heptyl-4-Hydroxyquinoline;KF-8940;Pyo-II

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HQNO Catalog No. CSN26126

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